Application of hesperidin and/or naringin in preparation of medicine for improving cognitive disorder

A technology for cognitive dysfunction and cognitive improvement, which is applied in the field of application of hesperidin and/or naringin in the preparation of drugs for improving cognitive dysfunction, can solve problems that have not yet been discovered, achieve significant technical effects, reduce MDA activity and the effect of increasing SOD activity

Inactive Publication Date: 2018-02-16
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] According to CN1704065A records, hesperidin and / or naringin can be used as bittering agents and sweating agents, and also have the functions of lowering cholesterol, treating acute and chronic bronchitis, and promoting gastric motility, but hesperidin and / or naringin have not been found yet. It has the effect of improving cognitive dysfunction drugs

Method used

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  • Application of hesperidin and/or naringin in preparation of medicine for improving cognitive disorder
  • Application of hesperidin and/or naringin in preparation of medicine for improving cognitive disorder
  • Application of hesperidin and/or naringin in preparation of medicine for improving cognitive disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of hesperidin and / or naringin

[0038] Citrus aurantium fine powder 600g, extract 3 times with 70% ethanol (crude drug: solvent weight ratio is 1:8; 1:6; 1:6), combine the extracts, recover ethanol until it has no alcohol smell, add distilled water to 600ml, water The solution was sequentially extracted with petroleum ether, ethyl acetate and n-butanol, 300ml each time. The n-butanol extraction part was concentrated and dried to obtain 82g, which was put on a D101 macroporous resin column, and eluted with water, 25% ethanol, 50% ethanol and 95% ethanol in sequence, and the 50% ethanol eluted part was concentrated and dried to obtain 20% The above mixed total glycosides of hesperidin and naringin (47g) were separated by silica gel column chromatography to obtain pure products of hesperidin (95%, 20g) and naringin (95%, 15g). The chemical structures of the above two pure products were confirmed by comparing with the IR, UV, NMR, m.p. and TLC...

Embodiment 2

[0039] Embodiment 2: the preparation of hesperidin and naringin mixture

[0040] Hesperidin (2 g) obtained in Example 1 and naringin (18 g) were thoroughly mixed at a ratio of 1:9, stirred and ground to obtain a mixture (20 g) of hesperidin and naringin.

Embodiment 3

[0041] Embodiment 3: the preparation of hesperidin and naringin mixture

[0042] Hesperidin (10 g) obtained in Example 1 and naringin (10 g) were fully mixed in a ratio of 1:1, stirred and ground to obtain a mixture (20 g) of hesperidin and naringin.

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Abstract

The invention relates to the application of hesperidin and/or naringin in the preparation of drugs for improving cognitive dysfunction.

Description

technical field [0001] The invention relates to the application of hesperidin and / or naringin in the preparation of drugs for improving cognitive dysfunction. Background technique [0002] Alzheimer's disease is a mental impairment syndrome that occurs in the early and old age and is characterized by brain dysfunction characterized by progressive dementia. Including senile dementia, also known as Alzheimer's disease (Alzheimer disease, AD for short) and cerebrovascular dementia (Vascular dementia, VD for short). Among them, AD is a primary central nervous system degenerative disease that occurs in middle-aged and elderly people; VD is dementia caused by brain damage caused by cerebrovascular disease. The etiology of VD involves two aspects, namely, cerebrovascular disease and risk factors. Risk factors include risk factors for cerebrovascular disease (hypertension, hyperlipidemia, heart disease, diabetes, common arteriosclerosis, smoking), stroke, ischemic leukoencephalopa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/28
CPCA61K31/7048
Inventor 黄冰峰王章伟陈玲蔡群芳谢华萍胡长玲王冠楠
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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