A non-invasive detection system for the immune status of transplanted kidney

A detection system and state technology, applied in the direction of organ motion/change detection, ultrasonic/sonic/infrasonic Permian technology, medical science, etc., can solve the problems of complicated process, unfavorable burden on medical staff, inconvenience, etc., and reduce labor intensity , The effect of simple structure and convenient maintenance

Active Publication Date: 2019-07-05
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above technologies involve more data processing and complicated procedures during the use of doctors, which is not conducive to reducing the burden on the increasingly heavy medical staff. Further automation and semi-automation are needed in diagnostic practice, so that doctors can focus more on case results. Only by analyzing rather than specific process processing and reducing labor intensity can new medical technology solutions be popularized faster
[0004] In summary, there are obviously inconveniences and defects in the actual use of the existing technology, so it is necessary to improve

Method used

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  • A non-invasive detection system for the immune status of transplanted kidney
  • A non-invasive detection system for the immune status of transplanted kidney
  • A non-invasive detection system for the immune status of transplanted kidney

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Preferred embodiment 1, the non-invasive detection system 100 of the transplanted kidney immune status of the present invention evaluates the immune status of the transplanted kidney within 1 month after operation:

[0105] 1. Patient inclusion

[0106] Patients with acute renal allograft rejection (16 cases), acute tubular necrosis (14 cases) and stable allografted kidney (28 cases) confirmed by renal biopsy were selected. Relevant materials and data are obtained through the Internet through the data management module 10 .

[0107] 2. Calculation of E value

[0108] This step is realized by the first calculation module 31, A1, B1, C1, D1 are taken as -4.222, 2.109, 0.026, 0.043, the calculation process is as follows:

[0109] E=e P / (1+e P )

[0110] where P=-4.222+2.109×SWS–0.026×eGFR+0.043×KC

[0111] SWS is shear wave velocity from elastosonography, eGFR is estimated glomerular filtration rate, and KC is rate of change in graft volume.

[0112] 3. Comparison ...

Embodiment 2

[0114] Preferred embodiment 2, the noninvasive detection system of the transplanted kidney immune status of the present invention evaluates the immune status of the transplanted kidney after one month after operation:

[0115] 1. Patient inclusion

[0116] Patients with acute renal allograft rejection (16 cases), acute tubular necrosis (14 cases) and stable allografted kidney (28 cases) confirmed by biopsy within 1 month after renal transplantation were selected. In addition, patients with acute rejection (41 cases), chronic rejection (25 cases) and stable graft kidney (37 cases) confirmed by renal transplantation biopsy more than 1 month after renal transplantation were selected.

[0117] 2. Calculation of E value

[0118] E=e P / (1+e P )

[0119] where P=-4.222+2.109×SWS–0.026×eGFR+0.043×KC

[0120] SWS is shear wave velocity from elastosonography, eGFR is estimated glomerular filtration rate, and KC is rate of change in graft volume. A1, B1, C1, and D1 are taken as -4...

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Abstract

A system (100) for noninvasively detecting an immune state of a transplanted kidney is applicable to the technical field of ultrasonic diagnosis automation after a kidney transplantation operation. The system (100) for noninvasively detecting an immune state of a transplanted kidney comprises: a data management module (10), used for obtaining, by means of networking, personal data and ultrasonic detection data of a patient for one or more times of detection according to identity recognition information of the patient; an ultrasonic connection module (20), used for accessing an ultrasonic detector and importing current ultrasonic detection data of the transplanted kidney; an analysis and processing module (30), used for selecting a computing model according to the personal data of the patient, and obtaining an analysis result of the ultrasonic detection data; and a result output module (40), used for formatting the analysis result and outputting the result according to the transplanting time of the patient and the analysis processing result. Accordingly, the system (100) collects and obtains clinical data and ultrasonic detection data of a patient, performs automatic / semi-automatic module combination, performs automatic classification operation, and finally, outputs an image-text integrated result, reduces the working load of a doctor, and facilitates result understanding.

Description

technical field [0001] The invention is suitable for the technical field of ultrasonic diagnosis automation after kidney transplantation, and in particular relates to a non-invasive detection system for the immune state of transplanted kidneys. Background technique [0002] Kidney transplantation is currently the most mature organ transplant operation in the world, with the largest number of operations. After kidney transplantation, patients need to take immunosuppressive agents for life-long anti-rejection therapy. Despite the rapid development of immunosuppressants, rejection and early postoperative acute tubular necrosis (acute tubular injury, ATN) are still inevitable. Acute rejection (acute rejection, AR) can occur at any time after surgery, leading to rapid deterioration of renal function. Chronic rejection (chronic rejection, CR) mainly occurs in the long-term after operation, and is still the key factor restricting the long-term survival of transplanted kidneys. C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B8/08
CPCA61B8/08A61B8/48A61B8/481A61B8/485A61B8/488
Inventor 何婉媛王文平朱同玉杨橙吴盛迪
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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