Detection method of traditional Chinese medicine composition for treating chronic pharyngitis

A technology for chronic pharyngitis and detection method, which is applied in the directions of drug combination, pharmaceutical formula, measuring device, etc., can solve the problems of inability to control the quality of products, disadvantageous to the overall control of product quality of manufacturers and supervision departments, etc.

Active Publication Date: 2018-02-02
滨州医学院附属医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The above-mentioned granules do not have relevant methods for testing them, so their quality cannot be contro...

Method used

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  • Detection method of traditional Chinese medicine composition for treating chronic pharyngitis
  • Detection method of traditional Chinese medicine composition for treating chronic pharyngitis
  • Detection method of traditional Chinese medicine composition for treating chronic pharyngitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prepare the granule for the treatment of chronic pharyngitis, its specific preparation method is as follows:

[0042] Weigh 300g Scrophulariaceae, 200g Shegan, 200g Platycodon grandiflorum, 200g Radix Paeoniae Rubra, 100g Chrysanthemum, 100g Licorice, add 10 times the total weight of the above medicinal materials and decoct three times, decoct for 2 hours for the first time, and combine the decoction , filtered, and the filtrate was allowed to stand for 12 hours;

[0043] The supernatant is concentrated to a relative density of 1.32 to 1.35, and the relative density is 80 to 85° C.; the clear paste is taken, sucrose and dextrin are added, granulated and dried to obtain granules.

Embodiment 2

[0045] The content of 4 kinds of compositions in the granule of embodiment 1 is measured simultaneously by HPLC method

[0046] Shimadzu LC-2010CHT high performance liquid phase (Shimadzu, Japan); 1 / 100,000 analytical balance (SHIMADZUAUW120D, Japan); digital constant temperature water bath (Danrui HH-D4);

[0047]Acetonitrile (Fisher scientific); phosphoric acid (analytical grade, Sinopharm Group); water (wahaha pure water); sheganoside (batch number: 222041, Aladdin reagent), luteolin, cinnamic acid, irisaxanthin (batch number: SBJ- I0601, SBJ-I0901, SBJ-I0201, Nanjing Senbega Biotechnology Co., Ltd.) the purity of the reference substance is greater than 98%; Yanshu granules are self-made in the preparation room of the Pharmacy Department of the Affiliated Hospital of Binzhou Medical College (batch numbers: 161206, 161212, 161217) .

[0048] Chromatographic column: THERMO Hypersil GOLD C18 chromatographic column (4.6×250mm 5μm);

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a detection method of a traditional Chinese medicine composition for treating chronic pharyngitis. The detection method of the traditional Chinese medicine composition for treating the chronic pharyngitis comprises a step of determining contents of tectoridin, luteolin, cinnamic acid and tectorigenin by a HPLC method. According to the detection method of the traditional Chinese medicine composition for treating the chronic pharyngitis disclosed by the invention, a quality standard of a new preparation can be effectively and strictly formulated; according to a relationship of assistance and guidance, contents of effective ingredients of the traditional Chinese medicine in the preparation are determined, and an experimental research on stability in vitro on the preparation is carried out, so that a good foundation is laid for researching and developing new medicines.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a detection method of a traditional Chinese medicine composition for treating chronic pharyngitis. Background technique [0002] Chronic pharyngitis is called "slow throat paralysis" in traditional Chinese medicine, and it is also called "throat paralysis of yin deficiency" and "throat paralysis of deficiency fire" in some books. TCM syndrome differentiation is divided into: deficiency of lung and kidney yin, deficiency of fire and inflammation; weakness of spleen and stomach, loss of nourishment in the throat; deficiency of spleen and kidney yang, loss of warmth in the throat; phlegm coagulation and blood stasis, accumulation of throat. [0003] Chronic pharyngitis is chronic inflammation of pharyngeal mucosa, submucosal and lymphoid tissues. According to the severity of the disease, the disease can be divided into chronic simple ph...

Claims

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Application Information

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IPC IPC(8): G01N30/02A61K36/88A61K9/16A61P11/04
CPCA61K9/1652A61K36/287A61K36/346A61K36/484A61K36/65A61K36/71A61K36/808A61K36/88A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N30/02A61K2300/00
Inventor 吕文文张金杰樊其忠孙迎东
Owner 滨州医学院附属医院
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