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Application of a hydrogel in the preparation of electrodes for detecting electrocorticograms

A technology for detecting cerebral cortex and hydrogel, which is applied in the fields of application, diagnostic recording/measurement, medical science, etc. It can solve the problems of easily damaged brain tissue, poor biocompatibility, different conduction principles of the brain, etc. Cell generation, good biocompatibility, the effect of good biocompatibility

Active Publication Date: 2020-05-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During use, metal electrodes are easy to damage brain tissue and cannot fit tightly to the cerebral cortex
In addition, long-term in vivo recording cannot be achieved due to the poor biocompatibility of metal electrodes and the different conduction principles from the brain

Method used

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  • Application of a hydrogel in the preparation of electrodes for detecting electrocorticograms
  • Application of a hydrogel in the preparation of electrodes for detecting electrocorticograms
  • Application of a hydrogel in the preparation of electrodes for detecting electrocorticograms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Polyethylene glycol diacrylate was dissolved in cerebrospinal fluid, and an initiator was added to make a gel sheet 1, which was embedded in a flexible substrate 2 made of polydimethylsiloxane, and the pre-embedded silver sheet The inert metal sheet 3 is closely attached, and the inert metal sheet 3 is connected to the external instrument connector 4. made flexible electrodes such as figure 1 shown.

[0029] The above electrodes were placed in the brain of the mouse (strain C57), and after 3 weeks, the cortical field potential was connected to an external instrument detector, and the field potential signal was obtained as follows: image 3 shown.

[0030] Through the analysis of the field potential, it can be found that the field potential clearly shows the different activity states of the mouse, such as awake and sleeping. The experiment proves that the electrode is still usable after 2 weeks in the mouse body, and has good biocompatibility. The general electrocorti...

Embodiment 2

[0032] Polyethylene glycol diacrylate was dissolved in cerebrospinal fluid, and an initiator was added to make a gel, and the gel was injected into the brains of mice (strain C57). Filaments of platinum, the material used for conventional electrocorticography electrodes, were inserted into the brains of the same mice. Immunohistochemical staining was performed after 2 weeks to observe glial cell proliferation. Such as Figure 4 As shown, the left picture is the gel, and the right picture is the wire. Glial cells are excited to fluoresce under a microscope by a laser. It can be found that the glial cells of the gel are significantly less than those of the platinum wire. It shows that the gel has good biocompatibility in the brain environment.

Embodiment 3

[0034] Polyethylene glycol diacrylate was dissolved in cerebrospinal fluid, and an initiator was added to make a gel. The stress-strain curve of the gel measured with a tensile machine is as follows Figure 5 As shown, it can be obtained that the elastic modulus is 200Kpa, while the elastic modulus of the traditional metal electrode is on the order of 100Gpa, and the elastic modulus of the brain tissue is 10Kpa. This experiment proves that the elastic modulus of the gel is more compatible with the brain tissue, and the damage to the brain caused by the contact with the brain is smaller than that of the metal electrode.

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Abstract

The invention discloses the application of a hydrogel in the preparation of electrodes for detecting electrocorticograms. The invention is the first electrocorticogram collection technology using gels with low conductivity as electrodes. In the liquid environment of the brain, the gel conducts electricity through its free ions, and the directional movement of the ions forms an electric current, achieving a detection effect comparable to that of highly conductive materials. At the same time, the gel can form an excellent mechanical property match with the brain tissue, and can closely fit the cerebral cortex. Its excellent biocompatibility can avoid biological rejection. This method not only greatly improves the physiology of traditional ECC, but also promises to achieve long-term ECO recording for more functions.

Description

technical field [0001] The invention relates to the application of a hydrogel with low electrical conductivity, in particular to the application of a hydrogel in preparing electrodes for detecting electrocorticograms. Background technique [0002] Electrocorticography is an essential technique in the Montreal course (used in the treatment of epilepsy in critically ill patients). EEG cortical potentials were recorded to identify the cortical regions producing seizures. This area of ​​cortex is then surgically removed to remove the source of the seizures. It is generally believed that the signals emitted by brain cells are weak, and those skilled in the art usually use metal materials with high electrical conductivity as detection electrodes for brain signals. However, metal electrodes have extremely high hardness and poor biocompatibility, and different conduction principles from the brain (the brain conducts ions while the metal conducts electrons). During use, metal elec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/0478A61L31/14A61L31/04
CPCA61L31/04A61L31/14A61B5/291A61B5/293
Inventor 汪浩盛昊
Owner ZHEJIANG UNIV
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