Transdermal liquid preparation

Abstract

The present invention addresses the problem of providing a liquid preparation for external application, which has a shortened transdermal absorption lag time and has excellent transdermal absorption properties. The present invention also addresses the problem of providing a liquid preparation for external application, which is less irritative to skin. The problems can be solved by a transdermal liquid preparation comprising: (a) propylene glycol in an amount of 40 to 98% by weight; (b) phosphatidylcholine in an amount of 0.1 to 5% by weight; (c) oleyl alcohol and / or isostearyl alcohol in an amount of 0.1 to 10% by weight; and (d) a medicine in an amount of 0.1 to 25% by weight. It is preferred that the transdermal liquid preparation additionally contains an alkanol amine. The alkanol amineis preferably triethanolamine.

Description

technical field [0001] The present invention relates to a percutaneous absorption type liquid preparation. Specifically, the present invention relates to an external preparation composition containing medicine and phosphatidylcholine. Background technique [0002] As a technique for transdermally absorbing various drugs, there is known a percutaneous absorption type liquid preparation in which drugs and phosphatidylcholine are dissolved in a propylene glycol solvent to form a colloidal dispersion (Patent Document 1). This technology has shown a high effect in the skin penetration of various drugs with a simple composition. However, depending on the type of drug, it is sometimes required to achieve extremely high absorbability in a short period of time, and it is necessary to further increase skin permeability. [0003] On the one hand, in order to improve the transdermal absorbability, some documents propose to add transdermal absorption enhancers such as higher fatty acid...

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Problems solved by technology

[0003] On the one hand, in order to improve the transdermal absorbability, some documents propose to add transdermal absorption enhancers such as higher fatty acid, higher alcohol, fatty acid ester (for example, patent documents 2 and 3), but, about containing propylene glycol and phosphatidylcholine Colloidal liquid formulations of bases, techniques to shorten the lag time of transdermal absorption and improve skin permeability have not been proposed

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