Method for preparing hydrogel dressing containing nano-silver chloride particles

Abstract

The invention provides a method for preparing a hydrogel dressing containing nano-silver chloride particles and relates to the biomedical field. The specific preparation method of the hydrogel dressing comprises the following steps of firstly preparing the nano-silver chloride particles by virtue of a microemulsion method, wherein the diameters of the nano-silver chloride particles are about 40nm,and the particle sizes of the nano-silver chloride particles are uniform; and carrying out blending a nano-silver chloride water solution with a certain mass fraction of Carbomer, and uniformly stirring, so as to obtain the hydrogel dressing with good antibacterial effects to escherichia coli and staphylococcus aureus. By adjusting and controlling the content of the nano-silver chloride particles, the antibacterial effects of the hydrogel dressing can be effectively adjusted. The method has the beneficial effects that the process is simple, the tedious operation step is avoided, and the hydrogel dressing prepared through physical blending can be used as a medical wound dressing, has relatively good medical value and is easy for large-scale industrial production.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method for preparing a hydrogel dressing containing nanometer silver chloride particles and its antibacterial application. Background technique [0002] Silver chloride is a photocatalyst that can respond to visible light, and has high antibacterial activity and stable physical and chemical properties. The preparation and performance research of silver chloride antibacterial materials have been paid attention in recent years. Among them, the bactericidal mechanism of silver chloride nanoparticles: when a small amount of ionized Ag + When it reaches the microbial cell membrane (negatively charged), the electrostatic force makes the two adsorb, and the Ag + It penetrates the cell wall and enters the cell, reacts with thiol (-SH) to coagulate the protein, destroys the activity of cell synthetase, and the cell loses the ability to divide and proliferate and dies. Ag + It can also des...

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Problems solved by technology

Although the antibacterial product prepared in the above method has significant antibacterial effect, the operation is complicated, the steps are cumbersome, and the in-situ generation cannot control the uniformity of the particle size of the nano-silver chloride particles.

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