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Small molecule marker for predicting lymphatic metastasis of lung cancer and application to diagnosis

A technology for lymph node metastasis and lung cancer, applied in the field of precise diagnosis, can solve the problems of difficulty in sampling materials, difficult detection of small lesions, and inability to meet the early diagnosis of lymph node metastasis of lung cancer, etc., and achieve the effect of high clinical diagnostic value.

Active Publication Date: 2018-01-16
WUHAN METVILLE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The gold standard for the diagnosis of lymph node metastasis in lung cancer is pathological examination. This method has high specificity, but it is traumatic, not easy for patients to accept, and it is difficult to obtain materials
Imaging examination is currently the main method for the diagnosis of lymph node metastasis of lung cancer, but it is costly and difficult to detect small lesions, which cannot meet the requirements of early diagnosis of lymph node metastasis of lung cancer

Method used

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  • Small molecule marker for predicting lymphatic metastasis of lung cancer and application to diagnosis
  • Small molecule marker for predicting lymphatic metastasis of lung cancer and application to diagnosis
  • Small molecule marker for predicting lymphatic metastasis of lung cancer and application to diagnosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Accuracy of Small Molecular Markers in Predicting Lung Cancer Lymph Node Metastasis

[0020] 1. Materials and methods

[0021] 1. Research object

[0022] Patients in the lung cancer lymph node metastasis group and lung cancer non-lymph node metastasis group were hospitalized in Nanjing Drum Tower Hospital from March 2015 to December 2016. There were 60 cases in the lung cancer lymph node metastasis group, including 34 males, 26 females, and aged 38. -72 years old, with an average age of 45 years; there were 100 cases in the lung cancer non-lymph node metastasis group, including 62 males and 38 females, aged 35-70 years, with an average age of 43 years. All cases were confirmed clinically and pathologically. Patients in the lung cancer lymph node metastasis group and lung cancer non-lymph node metastasis group were randomly divided into two groups, one was the training set and the other was the validation set. The grouping results are as follows.

[0023] ...

Embodiment 2

[0052] Embodiment 2: Diagnostic kit

[0053] A diagnostic kit for early prediction of lymph node metastasis in lung cancer, including phosphatidylinositol (18:3 / 0:0), lysophosphatidylcholine (18:1), phenylalanine and L-2-chloro Phenylalanine, phosphatidylinositol (18:3 / 0:0), lysophosphatidylcholine (18:1), and phenylalanine were used as reference substances to qualitatively locate the target compound in the serum to be tested, L-2 -Chlorophenylalanine was used as an internal standard and added to the serum sample to be tested for relative quantification of lysophosphatidylcholine (18:1), phosphatidylinositol (18:3 / 0:0), and phenylalanine.

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Abstract

The invention discloses a small molecule marker for predicting lymphatic metastasis of lung cancer and application to diagnosis, and discloses a composition for predicting the lymphatic metastasis ofthe lung cancer. The small molecule marker at least comprises phosphatidylinositol (18:3 / 0:0), and preferably comprises phosphatidylinositol (18:3 / 0:0), lysophosphatidylcholine (18:1) and phenylalanine, wherein the phosphatidylinositol (18:3 / 0:0) is used for singly diagnosing that the AUC (area under the curve) of the lymphatic metastasis of the lung cancer and the non-lymphatic metastasis of thelung caner is 0.803, and the accuracy is medium; the phosphatidylinositol (18:3 / 0:0), the lysophosphatidylcholine (18:1) and the phenylalanine are used for jointly diagnosing that the AUC of the lymphatic metastasis of the lung cancer and the non-lymphatic metastasis of the lung caner is 0.937, and the accuracy is higher; the sensitivity and specificity at the optimum diagnosis critical value respectively reach 0.9 or above. After centralized further verifying by independent samples, the small molecule marker has the advantages that the accuracy of the phosphatidylinositol (18:3 / 0:0), the lysophosphatidylcholine (18:1) and the phenylalanine for jointly diganosing the lymphatic metastasis of the lung cancer and the non-lymphatic metastasis of the lung caner reaches 95%, and the clinical value is higher.

Description

technical field [0001] The invention belongs to the field of precise diagnosis and relates to a diagnostic marker and a diagnostic kit, in particular to a small molecular marker for predicting lymph node metastasis of lung cancer and its application in diagnosis. Background technique [0002] Lung cancer is a common malignant tumor. Its morbidity and mortality rank first among all kinds of malignant tumors, and it continues to rise. In the late stage of lung cancer, metastases to different organs can occur, which can cause corresponding symptoms, often bring great pain to patients, and even threaten their lives. Among them, lymph node metastasis of lung cancer is the most common. Lymph node metastasis of lung cancer is extremely occult, without any symptoms in the early stage, and the optimal treatment time window has been missed by the time of pathological diagnosis. [0003] The gold standard for the diagnosis of lymph node metastasis in lung cancer is pathological exami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
Inventor 王玉梅董明淑曹阳吴桐
Owner WUHAN METVILLE MEDICAL TECH CO LTD
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