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Preparation for degrading drug residues in aquatic animals

A technology for aquatic animals and preparations, which is applied in the directions of drug combinations, medical preparations containing active ingredients, antidote, etc., can solve the problem of single drug residues, etc., and achieves the effect of convenient use, simple method and degrading drug residues.

Active Publication Date: 2017-12-29
ZHONGHEFA BEIJING BIOLOGICAL SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned composition has the disadvantage that it is slightly single in degrading drug residues in aquatic animals.

Method used

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  • Preparation for degrading drug residues in aquatic animals
  • Preparation for degrading drug residues in aquatic animals
  • Preparation for degrading drug residues in aquatic animals

Examples

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preparation example Construction

[0026] The preparation method of described aminopolysaccharide calcium is as follows:

[0027] S1. Dry the crab shell first, then crush it to 60-80 mesh, add water and stir, let stand at room temperature to swell; then heat to 56-58°C, add mixed enzyme according to the weight percentage of 0.6% of crab shell powder raw material , mixed enzyme is made up of protease, amylase and cellulase, and their molar ratio is protease: amylase: cellulase=0.8-1.2:1.8-2.2:4.5-5.5, adjust pH=6.5-7.5, stir enzymolysis Finally, filtrate and clean crab shell powder are obtained by filtration; after soaking the crab shell powder in hydrochloric acid for decalcification, adding sodium hydroxide to neutrality, filtering, washing, and drying to obtain chitin, and then adding an equimolar amount of acetic acid for deacetylation at 70°C Denaturation for 2-4 hours to obtain amino polysaccharides;

[0028] S2, adding amino polysaccharide to dissolve in acetic acid, adding CaCl 2 , added until the crys...

Embodiment 1

[0030] A preparation for degrading drug residues in aquatic animals, comprising the following components by weight:

[0031] Amino polysaccharide calcium 50 parts, licorice 20 parts, Radix isatidis 15 parts, bezoar 15 parts;

[0032] The amino polysaccharide salt has a molecular weight of 1.2 million and a deacetylation degree of 80%.

[0033] A preparation for degrading drug residues in aquatic animals is prepared by uniformly mixing amino polysaccharide calcium, licorice, isatidis and bezoar.

[0034] Take the feed (the shrimp feed is selected from Guangdong Haid Group Penaeus vannamei Feed No. 2, the soft-shelled turtle feed is selected from Zhejiang Jinjia Aquatic Feed Co., Ltd.'s soft-shelled turtle feed, and the eel feed is selected from Foshan Haihuang Industrial Co., Ltd.'s mature eel powder) 50kg, get above-mentioned preparation 100g to be dissolved in water and spray on feed, after spraying evenly, can make bait 1-1 (prawn), 1-1 (turtle), 1-1 (eel) after drying.

Embodiment 2

[0036] A preparation for degrading drug residues in aquatic animals, comprising the following components by weight:

[0037] 30 parts of amino polysaccharide calcium, 25 parts of licorice, 2 parts of isatidis, 2 parts of bezoar;

[0038] The amino polysaccharide salt has a molecular weight of 1.5 million and a deacetylation degree of 82%.

[0039] A preparation for degrading drug residues in aquatic animals is prepared by uniformly mixing amino polysaccharide calcium, licorice, isatidis and bezoar.

[0040]Take 50 kg of feed (grass carp feed is selected from Guangdong Haid Group 707 grass carp feed), take 100 g of the above preparation and dissolve it in water and spray it on the feed. After spraying evenly, dry it to prepare bait 1-2.

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Abstract

The invention discloses a preparation for degrading drug residues in aquatic animals. The preparation is prepared from the following components in parts by weight: 30-60 parts of calcium glycosaminoglycan, 20-35 parts of radix glycyrrhizae, 2-20 parts of radix isatidis and 2-20 parts of calculus bovis. The preparation is prepare from glycosaminoglycan salt, radix glycyrrhizae, radix isatidis and calculus bovis through mixing, the components are compounded to achieve a function of synergistic detoxification, and the drug residues in the aquatic animals can be effectively degraded; the preparation can be added for a long time in the whole culture process, is ecological, green and pollution-free, is suitable for reducing cost and improving output value in the modern high-density intensive culture mode and is an excellent choice for aquaculture in the future.

Description

technical field [0001] The invention belongs to the technical field of aquaculture, and in particular relates to a preparation for degrading drug residues in aquatic animals. Background technique [0002] Drug residues in aquatic products usually refer to the residues of parent compounds and / or their metabolites, as well as drug-related impurities in any edible part of aquaculture animals. In addition, drugs or their metabolites can covalently bind to endogenous macromolecules, forming binding residues, which have potential toxic effects on target animals. Therefore, drug residues include not only the original drug, but also the metabolites of the drug in animals, as well as the conjugates of the drug and endogenous molecules. The main residual drugs are disinfectants, insecticides, antibacterials (antibiotics, sulfonamides, furans), hormones, gene inducers, vaccines, etc. At present, with the continuous development of my country's aquaculture industry, there are problems ...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P39/02C08B37/08A61K31/726A61K35/413
CPCA61K31/726A61K35/413A61K36/195A61K36/315A61K36/484C08B37/0003C08B37/003A61K2300/00
Inventor 刘立明李海兵韦嵩张宁
Owner ZHONGHEFA BEIJING BIOLOGICAL SCI & TECH DEV
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