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Application of antrodia cinnamomea and monomer lanostane 32 in preventing and treating non-alcoholic fatty liver

A non-alcoholic, lanostane technology is applied to the application of Antrodia camphorata and monomer lanostane 32 in the prevention and treatment of non-alcoholic fatty liver, and the new application field of Antrodia camphorata and monomer lanostane 32 can solve the problems that have not yet been solved. Antrodia camphorata and monomer lanostane 32 and other problems

Inactive Publication Date: 2017-11-14
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no relevant report on the use of Antrodia camphorata and monomer lanostane 32 in the prevention and treatment of non-alcoholic fatty liver

Method used

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  • Application of antrodia cinnamomea and monomer lanostane 32 in preventing and treating non-alcoholic fatty liver
  • Application of antrodia cinnamomea and monomer lanostane 32 in preventing and treating non-alcoholic fatty liver
  • Application of antrodia cinnamomea and monomer lanostane 32 in preventing and treating non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1, the inhibitory effect of the fruiting body extract (AC) / lanostane 32 (DEA32) of Antrodia camphorata on methionine and choline deficiency (methionine choline deficient diet, MCD) diet-induced non-alcoholic fatty liver in mice

[0052] 1. Preparation of mouse non-alcoholic fatty liver model induced by methionine and choline deficiency (methionine choline deficient diet, MCD) diet

[0053] 8-week-old male C57BL / 6 (Speyford (Beijing) Biotechnology Co., Ltd.) or C57BL / 6 background acetaldehyde dehydrogenase knockout (ALDH2KO) mice (from Jackson Laboratory, bred by Peking University Cardiovascular Institute) , the average body weight of 25g, use the common breeding feed of mice (the Experimental Animal Center of Academy of Military Medical Sciences to feed while feeding, add MCD feed (Nantong Trophy Feed Technology Co., Ltd., its product catalog number is TP36006) after the transition for 3 days, give simple MCD feed Feed and gavage 0.5% (0.5g / 100ml) sodium carboxy...

Embodiment 2

[0134] Example 2, the inhibitory effect of the fruiting body extract (AC) of Antrodia camphorata on the non-alcoholic fatty liver of mice induced by high fat diet (high fat diet, HFD)

[0135] 1. Preparation of mouse non-alcoholic fatty liver model induced by high fat diet (HFD)

[0136] The male C57BL / 6 mice of 8 weeks old, body weight average 25g, use common breeding feed for mice to feed while, add HFD feed (Nantong Trophy Feed Science and Technology Co., Ltd., its product catalog number is TP23200) after the transition 3 days, change After feeding with complete HFD diet for 6 consecutive weeks (that is, 1.5 months, abbreviated as 1.5M), the HFD-induced mouse non-alcoholic fatty liver model was obtained.

[0137] 2. Study on the inhibitory effect of the fruiting body extract of Antrodia camphorata (AC) on non-alcoholic fatty liver in mice induced by HFD

[0138] 1. Test grouping and treatment

[0139] Preparation of 0.5% CMC-Na containing AC: Weigh a certain mass of AC an...

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Abstract

The invention discloses application of antrodia cinnamomea and monomer lanostane 32 in preventing and treating non-alcoholic fatty liver. The novel specific application of the antrodia cinnamomea and the monomer lanostane 32, provided by the invention, is application of the antrodia cinnamomea, a fruiting body extract of the antrodia cinnamomea, a monomeric compound obtained by separation from the fruiting body extract of the antrodia cinnamomea, the lanostane 32 or a substance containing all the above materials in a product for treating and / or preventing the non-alcoholic fatty liver. Experiments prove that by using the antrodia cinnamomea and the monomer lanostane 32, the deposit rate of lipid in liver of a sicken body with the non-alcoholic fatty liver is reduced, the content of total triglyceride is reduced, expression levels of inflammatory factors and fibrosis related factors are reduced, the content of 4-hydroxynonenal in serum is reduced, as well as deposition of the lipid in the body liver caused by the non-alcoholic fatty liver, and increase of body weight and liver weight also can be prevented. Therefore, the antrodia cinnamomea and the monomer lanostane 32 have important effects on preventing and treating the non-alcoholic fatty liver.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new application of Antrodia camphorata and monomeric lanosterane 32, specifically the application of Antrodia camphorata and monomeric lanosterane 32 in preventing and treating non-alcoholic fatty liver. Background technique [0002] Nonalcoholic fatty liver disease, also known as nonalcoholic fatty liver disease (NAFLD), is a clinicopathological syndrome with liver histological changes similar to alcoholic liver disease but without a history of excessive alcohol consumption. Its pathological changes show simple fatty liver, steatohepatitis, fatty liver fibrosis and liver cirrhosis with the progress of the disease course. In recent years, the incidence of NAFLD has shown an obvious upward trend, and it has become the first major cause of chronic liver disease and abnormal liver function in developed countries. The prevalence of NAFLD in ordinary adults is 17% to 33%. [0003] At prese...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61K31/575A61P1/16
CPCA61K31/575A61K36/07
Inventor 祁荣徐璐
Owner PEKING UNIV
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