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Preparation method of captopril-loading polyvinyl alcohol-chitosan nanometer fiber

A technology of chitosan nano and polyvinyl alcohol, which is applied in fiber treatment, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of drug burst release, poor fiber formation, high toxicity, etc., and achieve simple control , easy to operate, good physiological compatibility

Inactive Publication Date: 2017-11-10
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are reports on the synthesis of captopril derivatives and the preparation of sustained-release microspheres, but captopril microsphere preparations are prone to sudden drug release, and more toxic formaldehyde is used in the preparation process, and drugs are directly added The nanofibers spun by captopril can be seen to have a lot of lumps, and the fiber formation is not good

Method used

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  • Preparation method of captopril-loading polyvinyl alcohol-chitosan nanometer fiber
  • Preparation method of captopril-loading polyvinyl alcohol-chitosan nanometer fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The first step S1: Add 1g of polyvinyl alcohol particles into 9ml of deionized water, after fully swelling, put it on a magnetic heating stirrer for heating and stirring in a water bath, the temperature of the water bath is 80°C, and keep it warm for 3 hours until the solution no longer contains micro Granules to produce a transparent polyvinyl alcohol solution.

[0028] Step 2 S2: Dissolve 0.1 g of chitosan in 10 ml of deionized water, add 3 drops of acetic acid dropwise, place on a magnetic stirrer, and stir at room temperature until the solution becomes clear.

[0029] Step 3 S3: Take 2ml of the solution in S2 and add it dropwise to the polyvinyl alcohol solution in S1 above to prepare a PVA-CS precursor solution.

[0030] Step 4 S4: Take one captopril tablet, dissolve it in 10ml deionized water, stir for 2h, take 2ml supernatant, add it dropwise to the above S3 precursor solution and stir for 1h to prepare spinning solution.

[0031] The fifth step S5: Control the ...

Embodiment 2

[0033] The first step S1: Add 1g of polyvinyl alcohol particles into 9ml of deionized water, after fully swelling, put it on a magnetic heating stirrer for heating and stirring in a water bath, the temperature of the water bath is 80°C, and keep it warm for 3 hours until the solution no longer contains micro Granules to produce a transparent polyvinyl alcohol solution.

[0034] Step 2 S2: Dissolve 0.1 g of chitosan in 10 ml of deionized water, add 3 drops of acetic acid dropwise, place on a magnetic stirrer, and stir at room temperature until the solution becomes clear.

[0035] Step 3 S3: Take 2ml of the solution in S2 and add it dropwise to the polyvinyl alcohol solution in S1 above to prepare a PVA-CS precursor solution.

[0036] Step 4 S4: Take one captopril tablet, dissolve it in 10ml deionized water, stir for 2h, take 2ml supernatant, add it dropwise to the above S3 precursor solution and stir for 1h to prepare spinning solution.

[0037] The fifth step S5: Control the ...

Embodiment 3

[0039] The first step S1: Add 1g of polyvinyl alcohol particles into 9ml of deionized water, after fully swelling, put it on a magnetic heating stirrer for heating and stirring in a water bath, the temperature of the water bath is 80°C, and keep it warm for 3 hours until the solution no longer contains micro Granules to produce a transparent polyvinyl alcohol solution.

[0040] Step 2 S2: Dissolve 0.1 g of chitosan in 10 ml of deionized water, add 3 drops of acetic acid dropwise, place on a magnetic stirrer, and stir at room temperature until the solution becomes clear.

[0041] Step 3 S3: Take 2ml of the solution in S2 and add it dropwise to the polyvinyl alcohol solution in S1 above to prepare a PVA-CS precursor solution.

[0042] Step 4 S4: Take one captopril tablet, dissolve it in 10ml deionized water, stir for 2h, take 2ml supernatant, add it dropwise to the above S3 precursor solution and stir for 1h to prepare spinning solution.

[0043] The fifth step S5: Control the ...

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Abstract

The invention discloses a preparation method of a captopril-loading polyvinyl alcohol-chitosan nanometer fiber. The preparation method comprises: S1, adding polyvinyl alcohol into deionized water to obtain a polyvinyl alcohol solution; S2, weighing chitosan, dissolving in deionized water, and adding 3 drops of acetic acid to obtain a clarified chitosan solution; S3, taking the chitosan solution obtained in the step S2, and adding to the polyvinyl alcohol solution obtained in the step S1 in a dropwise manner to prepare a PVA-CS precursor solution; S4, taking a captopril tablet, dissolving in deionized water, taking the supernatant, adding to the PVA-CS precursor solution obtained in the step S3 in a dropwise manner, and stirring to prepare a spinning solution; and S5, carrying out electrospinning on the spinning solution obtained in the step S4 to prepare the captopril-loading polyvinyl alcohol-chitosan nanometer fiber. According to the present invention, the optimal raw material ratio and the optimal preparation condition are provided, the captopril-loading polyvinyl alcohol-chitosan nanometer fiber is prepared by using the electrospinning technology, the advantages of simple structure, convenient operation, easy control and short process are provided, and the prepared captopril-loading polyvinyl alcohol-chitosan nanometer fiber can stably and slowly release and has good physiological compatibility.

Description

technical field [0001] The invention relates to a method for preparing nanofibers, in particular to a method for preparing nanofibers loaded with drugs. Background technique [0002] Chitosan (CS) has excellent properties such as pain relief, hemostasis, scar reduction, good physiological compatibility and biodegradability. However, because the film it forms is brittle and has poor mechanical properties, it is often used in combination with other biodegradable polymer materials. [0003] Captopril (CPL) is an antihypertensive drug widely used in clinic, which can effectively inhibit the activity of angiotensin converting enzyme. However, due to its short half-life, and its instability in the intestine, its absorption is easily affected by food, etc., which weakens its therapeutic effect. A large number of reports regard the study of drug sustained release as an effective method for improving the bioavailability of drugs. There are reports on the synthesis of captopril der...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/401A61K47/32A61K47/36A61P9/12D04H1/4382D04H1/728D01D5/00
Inventor 王菲菲王萍徐冬阳李鹏丽张岩刘福娟徐岚何吉欢
Owner SUZHOU UNIV
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