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Diagnostic marker for distinguishing VCA-IgA positive normal people from nasopharyngeal carcinoma people and application thereof

A technique for diagnostic markers and normal people, which is applied in the field of diagnostic markers and its application, can solve the problems of failure to rule out normal people who are positive for EBV antibodies, and achieve the effect of improving specificity and positive predictive value and reducing misdiagnosis

Inactive Publication Date: 2017-11-07
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

Although the positive predictive value has increased to a certain extent, it is still low, failing to achieve the expected goal of excluding most EBV antibody positive normal population

Method used

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  • Diagnostic marker for distinguishing VCA-IgA positive normal people from nasopharyngeal carcinoma people and application thereof
  • Diagnostic marker for distinguishing VCA-IgA positive normal people from nasopharyngeal carcinoma people and application thereof
  • Diagnostic marker for distinguishing VCA-IgA positive normal people from nasopharyngeal carcinoma people and application thereof

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Experimental program
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Embodiment Construction

[0046] The technical solution of the present invention will be further described below in combination with experiments.

[0047] Screening of novel diagnostic markers

[0048] Protein chip sequencing of 8 cases of nasopharyngeal carcinoma patients and 8 cases of VCA-IgA positive normal human serum: 8 cases of nasopharyngeal carcinoma and 8 cases of VCA-IgA normal human serum were sequenced by protein chip at Ruiboao Company, bioinformatics Analysis of differentially expressed proteins ( figure 1 ).

[0049] The results showed a total of 34 differentially expressed proteins, of which 24 were up-regulated and 10 were down-regulated ( figure 2 ), based on the principle of easy detection of markers, a total of 11 proteins with an up-regulated expression fold greater than 2 times were selected (Table 1).

[0050] Table 1. Differential proteins up-regulated more than 2 times in the protein chip

[0051]

[0052] Two nasopharyngeal carcinoma gene expression microarray databas...

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Abstract

The invention discloses a diagnostic marker and application for distinguishing VCA-IgA positive normal people from nasopharyngeal carcinoma. The diagnostic marker combination consists of CCL3, MIF and VCA-IgA. The inventors found serum markers for the diagnosis of nasopharyngeal carcinoma: CCL3 and MIF from the protein chips of nasopharyngeal carcinoma patient serum and VCA-IgA positive population serum. The established model of CCL3, MIF combined with traditional nasopharyngeal carcinoma diagnostic marker VCA‑IgA can be used to distinguish VCA‑IgA positive normal population from nasopharyngeal carcinoma population, which improves diagnostic specificity and positive predictive value, reduces misdiagnosis, and provides Diagnosis of nasopharyngeal carcinoma provides a new way.

Description

technical field [0001] The invention relates to a diagnostic marker and its application, in particular to a diagnostic marker for distinguishing VCA-IgA positive normal people from nasopharyngeal cancer patients and its application. Background technique [0002] Nasopharyngeal Carcinoma (NPC) is a malignant tumor that occurs frequently in South China and Southeast Asia, especially in Guangdong, my country. The pathogenic factors include Epstein-Barr Virus (EBV) infection, environment, genetics, and eating habits and other factors[1-3]. Among them, EBV infection is closely related to the occurrence of nasopharyngeal carcinoma. One of the most important means of cancer screening. [0003] At present, EBV capsid antigen IgA antibody (VCA-IgA) and EBV early antigen IgA antibody (EA-IgA) have been widely used in the physical examination and screening of nasopharyngeal carcinoma [4]. Deng Hong et al[5] reported that in Wuzhou, Guangxi, a high-incidence area of ​​nasopharyngeal c...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/558
CPCG01N33/57407G01N33/558
Inventor 刘万里曾木圣薛宁林建华
Owner SUN YAT SEN UNIV CANCER CENT
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