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Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging

A nanoparticle, neural tissue technology that addresses the lack of binding and/or spectral properties in formulations, applications, analysis using fluorescence emission, etc. in vivo

Inactive Publication Date: 2017-10-13
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, molecules such as distyrylbenzene and oxazines have been used but lack the binding and / or spectroscopic properties required to be effective for intraoperative applications in humans and other mammals

Method used

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  • Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
  • Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
  • Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging

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Embodiment Construction

[0067] Throughout the specification, where compositions are described as having, comprising, or comprising specified components, or where processes are described as having, comprising, or comprising specified steps, it is additionally contemplated that there are components consisting essentially of or consisting of the recited components The composition of the invention, and there are methods of the invention which consist essentially of or consist of the recited process steps.

[0068] It should be understood that the order of steps or order for performing certain actions is immaterial so long as the invention remains operable. Furthermore, two or more than two steps or actions may be performed simultaneously.

[0069] Reference herein to any publication in, for example, the Background section is not an admission that that publication serves as prior art with respect to any of the solutions presented herein. The Background section is presented for clarity and is not intended...

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Abstract

Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and / or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.

Description

[0001] Related Application Cross Reference [0002] This application claims the benefit of U.S. Provisional Application Serial No. 62 / 092,191, filed December 15, 2014, which is hereby incorporated by reference in its entirety. [0003] governmental support [0004] This invention was made with government support under Grant No. NIH NCI U54 CA199081-01 awarded by the National Institute of Health. technical field [0005] The present invention generally relates to cyclic peptides to cyclic peptide-conjugated nanoparticles and methods of using said cyclic peptides and / or said cyclic peptide-conjugated nanoparticles for intraoperative neural tissue imaging. Background technique [0006] Many surgical procedures carry the risk of accidental nerve damage or transection, which can create a host of problems such as chronic pain or paralysis. The use of near-infrared (NIR) agents to highlight neural tissue during surgery has been investigated, thereby enhancing the surgeon's abi...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61B5/00A61K9/00
CPCA61B5/0071A61B5/4893A61K9/0014A61K9/0019A61K49/0032A61K49/0056A61K49/0065A61K49/0093
Inventor 米歇尔·S·布拉德伯里巴内·游乌尔里希·维斯纳陈培明马凯斯尼哈尔·G·帕特尔达尼埃拉·卡拉萨瓦·扎诺尼
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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