Degradable and recoverable 4D printed linear organic body support and preparation method thereof

A human body and skeleton technology, applied in the field of human body stents, can solve problems such as low efficiency and achieve the effect of good human body compatibility

Active Publication Date: 2020-05-15
QINGDAO RONGSHANG TIANXIA NETWORK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical application of lumbrokinase is mainly in the form of oral medicine, the side effects include causing gastrointestinal reactions, and the efficiency of absorption through the digestive tract is relatively low

Method used

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  • Degradable and recoverable 4D printed linear organic body support and preparation method thereof
  • Degradable and recoverable 4D printed linear organic body support and preparation method thereof
  • Degradable and recoverable 4D printed linear organic body support and preparation method thereof

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preparation example Construction

[0037] In addition, the present invention also provides a preparation method for the above-mentioned human body support, comprising the following steps:

[0038] S1: Mix L-polylactic acid, D-polylactic acid and carboxymethyl chitosan uniformly at a mass ratio of 1:(0.8-1.1):(0.4-0.5) to obtain a mixed powder;

[0039] S2: Heat and melt the mixed powder at 130-155°C, and then use a mold to extrude a 4D printing raw material filament with a diameter of 1-3mm;

[0040] S3: Use 4D printing technology to print the 4D printing raw material filament into the preset shape of the human body bracket, and obtain the blank of the human body bracket;

[0041] S4: Immerse the human body stent blank into the functional protein film-coating solution for 2 to 5 seconds, then take it out and freeze-dry it at -40°C to obtain the semi-finished human body stent; wherein, the raw material group of the functional protein film-coating solution Parts include: 20 parts by weight of hirudin, 20 parts b...

Embodiment 1

[0045] This embodiment provides a human body support, such as figure 1 , figure 2 with image 3 As shown in the structure, the human body scaffold includes a skeleton part, a functional protein film and a chitosan film; the surface layer of the skeleton part is covered with a functional protein film, and the surface layer of the functional protein film is covered with a chitosan film; It is prepared from polylactic acid and carboxymethyl chitosan.

[0046] Specifically, the shape of the main outline structure of the human body support is a spiral tube, and the human body support includes a spiral part 8 and a mounting ring 1; wherein, the mounting ring 1 is located at both ends of the spiral part 8, and a fixing hole 2 is provided on the mounting ring 1 ; A chamfer is provided between the mounting ring 1 and the spiral portion 8 .

[0047] Specifically, the spiral part 8 includes a plurality of spiral units connected in sequence, and each spiral unit includes a circumferen...

Embodiment 2

[0049] This embodiment provides a method for preparing the human body stent shown in Embodiment 1, which includes the following steps:

[0050] S1: Mix L-polylactic acid, D-polylactic acid and carboxymethyl chitosan uniformly at a mass ratio of 1:0.8:0.4 to obtain a mixed powder;

[0051] S2: Heat and melt the mixed powder at 130°C, and then use a mold to extrude a 4D printing raw material filament with a diameter of 1mm;

[0052] S3: Use 4D printing technology to print the 4D printing raw material filament into the preset shape of the human body bracket, and obtain the blank of the human body bracket;

[0053] S4: Immerse the human body stent blank into the functional protein coating solution for 2 seconds, then take it out and freeze-dry it at -40°C to obtain the semi-finished human body bracket; wherein, the preparation method of the functional protein coating solution includes the following Steps: S101: Take 160g of hexafluoroisopropanol, add 20g of hirudin and 20g of lum...

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Abstract

The invention relates to a degradable and recyclable 4D printed linear organic human body stent and a preparation method thereof. The human body stent comprises a skeleton part, a functional protein film and a chitosan film, wherein the surface of the skeleton part is covered with the functional protein film, and the surface of the functional protein film is covered with the chitosan film; the skeleton part is prepared from polylactic acid and carboxymethyl chitosan. Polylactic acid and carboxymethyl chitosan adopted by the human body stent both have good compatibility with a human body and cannot have rejection; functional protein can have a thrombus ablation function and has good biocompatibility and bioabsorptivity; with adoption of a 4D memorable deformed printing material, the stent can provide effective support in earlier stage after being implanted into a stenosis position and guarantees vascular patency, after the stent is absorbed in later stage, a decomposition product of the stent can be absorbed and used by the body or discharged out of the body, no foreign body remains in a target blood vessel, the vasomotion function of the blood vessel is recovered to the largest extent, and secondary intervention is allowed.

Description

technical field [0001] The invention relates to the technical field of human body supports, in particular to a degradable and recoverable 4D printed linear organic human body support and a preparation method thereof. Background technique [0002] According to the data of "China's Health Statistics Summary", there are currently more than 270 million people with cardiovascular and cerebrovascular diseases in China, and the number of deaths caused by cardiovascular and cerebrovascular diseases is close to 40% of the total number of deaths in the country. It has become the "number one killer" of Chinese people's health . The main cause of cardiovascular disease is the deposition of excess fatty substances and calcium on the blood vessel wall to make it thicker, resulting in narrowing or blockage of blood vessels, resulting in difficulty in blood circulation, resulting in angina pectoris, myocardial infarction and even death. The main means of combating cardiovascular diseases i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/16A61L31/06A61L31/04A61L31/10
CPCA61L31/042A61L31/06A61L31/10A61L31/14A61L31/148A61L31/16A61L2300/252A61L2300/254A61L2300/42A61L2300/606A61L2420/08C08L67/04C08L5/08
Inventor 于永臣孙继泽程楷刘缵森
Owner QINGDAO RONGSHANG TIANXIA NETWORK CO LTD
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