Processing method and system for dynamic fluorescence molecular tomography

Abstract

The invention relates to a processing method and system for dynamic fluorescence molecular tomography. The method includes the steps of aiming at a to-be-analyzed object, collecting measurement data which is multi-spectrum and multi-time point dynamic fluorescence measurement data; based on the dynamic fluorescence measurement data, establishing three-dimensional fluorescence molecular tomography images under each spectrum and each time point; decomposing the three-dimensional fluorescence molecular tomography images to obtain the independent component information of each fluorescent target and spectral distribution information corresponding to the independent component information; according to the independent component information and the spectral distribution information, obtaining the three-dimensional metabolic parameter images used for representing the metabolic process of fluorescent molecular probes in the to-be-analyzed object. The processing method and system for the dynamic fluorescence molecular tomography contribute to reducing the morbidity of DFMT problems; in addition, on the basis of obtaining FMT images through reconstruction, multivariable analysis is carried out, and then metabolic parameter results are obtained aiming at each fluorescent target, so that the interference of other fluorescent targets and noise can be eliminated, and the accuracy of the reconstruction results can be improved.

Description

technical field [0001] The present invention relates to the technical field of dynamic fluorescence molecular tomography, and more particularly to a processing method and system for dynamic fluorescence molecular tomography. Background technique [0002] With the continuous development of optical imaging theory, imaging system and probe technology, in recent years, dynamic fluorescence molecular tomography (DFMT) technology has begun to attract the attention of scholars at home and abroad, and has been gradually applied in biology and medicine. researching. Different from static fluorescent molecular imaging technology, DFMT technology pays more attention to the complete process of absorption, distribution and excretion of fluorescent molecular probes in organisms. It is a dynamic imaging technology that can continuously monitor the physiological and pathological processes of organisms. DFMT technology can be used to directly observe the metabolic process of fluorescent mol...

AI Technical Summary

Problems solved by technology

[0003] In DFMT technology, first of all, due to the strong scattering characteristics of near-infrared light propagating in biological tissues, this leads to a great morbidity in the reverse problem of FMT (Fluorescence molecular tomography, fluorescence molecular tomography), that is, the image quality of the reconstruction results highly affected by noise

Secondly, because the metabolic process of fluorescent molecular probes in organisms has complex pathways, they will be dynamically distributed to different organs and tissues through the circulatory system, which will aggravate the morbidity of the reverse problem.

Therefore, the resolution and accuracy of metabolic parameter images obtained by traditional DFMT methods are relatively low

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