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Method for evaluating uncertainty of inspection results of drug component contents calculated by using external standard method

A technology of component content and degree of certainty, which is applied in the field of evaluation of the uncertainty of drug component content test results by the external standard method, can solve the problem of deviation from the true value, and achieve a reasonable calculation effect

Inactive Publication Date: 2017-09-05
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using a measuring system or measuring instrument to measure a standard sample, the measured results often deviate from the true value to a certain extent

Method used

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  • Method for evaluating uncertainty of inspection results of drug component contents calculated by using external standard method
  • Method for evaluating uncertainty of inspection results of drug component contents calculated by using external standard method
  • Method for evaluating uncertainty of inspection results of drug component contents calculated by using external standard method

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Embodiment 1

[0038] This embodiment is a method for evaluating the uncertainty of drug content determination results in test materials for drug-related cases, which is applicable to the uncertainty evaluation of the results of gas chromatography or liquid chromatography detection and external standard method calculation of drug content. The drug components in the test materials of drug-related cases are extracted with solvents, analyzed by gas chromatography (GC) or liquid chromatography (HPLC), and quantified by external standard method.

[0039] Calculation formula of measurement results and establishment of mathematical model

[0040] The quantitative mathematical model for determining the content of drug components in drug samples by gas chromatography or liquid chromatography is:

[0041]

[0042] In the formula: w—the percentage of drug components in the sample, %;

[0043] V 1 - the volume of the sample solution initially fixed to volume, mL;

[0044] V 2 - from V 1 The volu...

Embodiment 2

[0149] An evaluation method for calculating the uncertainty of drug component content test results by an external standard method, comprising the following steps:

[0150] (1) Utilize gas chromatography to determine the drug component content in the drug sample, and establish a quantitative mathematical model as:

[0151]

[0152] In the formula: w—the percentage of drug components in the sample, %;

[0153] V 1 - The volume of the sample solution to be fixed for the first time, 20mL;

[0154] V 2 - from V 1 Pipette the sample solution volume, 1mL;

[0155] V 3 - put V 2 Add solvent volume when diluting, 20mL;

[0156] A——The average value of the chromatographic peak area of ​​the drug components in the sample solution is 50;

[0157] A 0 - The average value of the chromatographic peak area of ​​the drug components in the standard working solution is 50;

[0158] C o - the concentration of drug components in the standard working solution, 0.1mg / mL;

[0159] m—th...

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Abstract

The invention discloses a method for evaluating the uncertainty of inspection results of drug component contents. The method comprises the following steps: construction of both a calculation formula and a mathematical model for measurement results; analysis of the sources of uncertainty; quantification of uncertainty components; calculation of synthesized standard uncertainty; calculation of expanded uncertainty; and expression of measurements. The method provided by the invention can accurately reflect main sources influencing uncertainty and can provide more reliable examination determination results.

Description

technical field [0001] The invention belongs to the field of forensic science drug analysis, and relates to an evaluation method for evaluating the uncertainty of drug component content test results calculated by an external standard method. It is suitable for the analysis of the uncertainty of the results of the measurement of drug content by liquid chromatography and gas chromatography. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/86
CPCG01N30/8675
Inventor 郑珲高利生张春水赵阳常颖贺剑锋翟晚枫李彭赵彦彪郑晓雨杨虹贤刘克林钱振华
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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