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Application of iron ion induced phenylalanine dipeptide self-assembled product in field of electrochemical chiral recognition

A technology of phenylalanine dipeptide and chiral recognition, which is applied in the field of biotechnology and electrochemical research, can solve the problems of weak coordination ability and achieve good recognition ability

Active Publication Date: 2017-08-29
CHANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The coordination number of zinc ion is 4, the coordination ability is weak

Method used

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  • Application of iron ion induced phenylalanine dipeptide self-assembled product in field of electrochemical chiral recognition
  • Application of iron ion induced phenylalanine dipeptide self-assembled product in field of electrochemical chiral recognition
  • Application of iron ion induced phenylalanine dipeptide self-assembled product in field of electrochemical chiral recognition

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Experimental program
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Effect test

Embodiment 1

[0028] (1) Preparation of iron ion-induced phenylalanine dipeptide self-assembly products: Add 20 μL of hexafluoroisopropanol to 1 mg of phenylalanine dipeptide to prepare 50 mg / mL phenylalanine dipeptide hexafluoroisopropanol Propanol solution, add ultrapure water to the above solution, and dilute to 3 mg / mL phenylalanine dipeptide self-assembly product. Then, 20 μL of iron ion solution was added to the phenylalanine dipeptide solution to obtain iron ion-induced phenylalanine dipeptide self-assembly products.

[0029] (2) Preparation of iron ion-induced phenylalanine dipeptide self-assembly product modified electrode: Use a pipette gun to pipette 5 μL of iron ion-induced phenylalanine dipeptide self-assembly product prepared in step (1) and drop it on the glass On the carbon electrode surface, after self-assembly at 30°C for 6 hours, the corresponding iron ion-induced phenylalanine dipeptide self-assembly product modified electrode can be obtained.

[0030] (3) The prepared ...

Embodiment 2

[0032] After the iron ion-induced phenylalanine dipeptide self-assembly product modified electrode prepared in Example 1 was placed in 25 mL of tryptophan enantiomer solution for 120 seconds, at 0.4-1.2 V (vs. SCE) Differential pulse characterization was performed within the electrochemical window. After each measurement, the modified electrode was swept in 25 mL of 0.1 M sodium dihydrogen phosphate (pH=7) to restore the electrode activity. The effect of iron ion-induced phenylalanine dipeptide self-assembly product modified electrode on the recognition of tryptophan enantiomers is shown in the attachment figure 2 As shown, the electrode modified by the self-assembly product of phenylalanine dipeptide induced by iron ion has a good recognition effect on the tryptophan enantiomer (ΔE is 72mV).

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Abstract

The invention relates to application of an iron ion induced phenylalanine dipeptide self-assembled product in the field of electrochemical chiral recognition. The application comprises the following steps: preparing the iron ion induced phenylalanine dipeptide self-assembled product, preparing iron ion induced phenylalanine dipeptide self-assembled product modified electrodes, and recognizing tryptophan enantiomers by an electrochemical method. The application has the beneficial effect that the iron ion induced phenylalanine dipeptide self-assembled product modified electrodes have relatively good recognition capability to the tryptophan enantiomers as a phenylalanine dipeptide has a certain chiral environment.

Description

technical field [0001] The invention relates to the application of an iron ion-induced phenylalanine dipeptide self-assembly product in the field of electrochemical chiral recognition, and belongs to the field of biotechnology and electrochemical research. technical background [0002] Protein is the material basis of life, the basic organic matter that constitutes cells, and the main bearer of life activities, and amino acid is the basic unit of protein. Therefore, the separation and analysis of amino acid enantiomers plays an extremely important role in life sciences, medicinal chemistry, and human health. Most amino acids have chiral isomers, and the physiological effects of the D- and L-enantiomers are quite different. Natural L-type amino acids in the human body can participate in protein synthesis, while D-type amino acids are inactive or harmful to the human body. Tryptophan is one of the essential amino acids for the human body and has been identified as the precur...

Claims

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Application Information

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IPC IPC(8): G01N27/48C07K5/065
CPCC07K5/06078G01N27/48
Inventor 孔泳郭莉丽鲍丽平
Owner CHANGZHOU UNIV
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