Aegiceras corniculatum leaf petroleum ether extract and its preparation method and use in treatment on prostatic cancer

A petroleum ether extraction and prostate cancer technology, which is applied in the direction of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., can solve problems that have not been reported yet

Inactive Publication Date: 2017-08-29
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

As for the research on the tung flower tree, it is mostly found in the stems, branches and bark of the tung flower tree, and more attention is paid to its ethanol and water extraction parts, and there is no report on the anti-cancer research on the petroleum ether part of the tung flower tree leaves

Method used

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  • Aegiceras corniculatum leaf petroleum ether extract and its preparation method and use in treatment on prostatic cancer
  • Aegiceras corniculatum leaf petroleum ether extract and its preparation method and use in treatment on prostatic cancer
  • Aegiceras corniculatum leaf petroleum ether extract and its preparation method and use in treatment on prostatic cancer

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Embodiment Construction

[0016] 1. Preparation of petroleum ether extract (PACL)

[0017] 1. Medicinal materials: The tung flower leaves were collected in Fangchenggang, Guangxi, and were identified by Xu Mingben of Guangxi Beibu Gulf Ocean Research Center as the leaves of the tung flower tree of the genus Candida of the Taurus family.

[0018] 2. Extraction and separation: Sun-drying Tung sylvatica leaves and beating them into coarse powder (2500g), adding 25 times the amount (62.5L) of 95% ethanol and soaking for 7 days; Concentrating under reduced pressure to obtain the Tung sylvatica leaves ethanol total extract, ethanol The total extract is dissolved in pure water to form a suspension. After heating and volatilizing until there is no ethanol smell, petroleum ether is added for extraction to obtain the upper layer petroleum ether part extract, and the upper layer petroleum ether part extract is dried in a water bath to obtain the oil of tungsten leaves. ether extract.

[0019] 2. Research on the ...

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Abstract

The invention provides aegiceras corniculatum leaf petroleum ether extract and a preparation method thereof. The preparation method comprises adding aegiceras corniculatum leaves into ethanol, soaking the aegiceras corniculatum leaves to obtain ethanol total extract of aegiceras corniculatum leaves, volatilizing the ethanol in the ethanol total extract, adding petroleum ether into the total extract, carrying out extraction, collecting petroleum ether extract in the upper layer, carrying out water bath treatment, and carrying out drying. An in-vitro molecular biology experiment result shows that the petroleum ether extract of the aegiceras corniculatum leaves can inhibit proliferation of human prostatic cancer cells PC3 and DU145 and significantly inhibit cloning formation of human prostatic cancer cells PC3 and DU145. Therefore, the petroleum ether extract of the aegiceras corniculatum leaves has a potential application prospect in preparation of drugs for treating prostatic cancer and can be used for preparation of an anti-prostatic cancer drug. Deep development of the aegiceras corniculatum leaf petroleum ether extract can enlarge a use range of aegiceras corniculatum and provide a novel approach for cancer treatment.

Description

technical field [0001] The invention belongs to the technical field of tung tree, and in particular relates to a tung tree leaf petroleum ether extract (PACL) and its preparation and application for treating prostate cancer. Background technique [0002] Aegiceras corniculatum (Aegiceras corniculatum) is a plant of the genus Aegiceras corniculatum, which is widely distributed among mangrove plants. Current research shows that its chemical components mainly contain terpenoids, steroids, flavonoids, polyphenols, etc., and its pharmacological effects are mainly cytotoxic, antifungal, antidiarrheal, and antioxidant. Due to the diversity and complexity of phytochemical components, even the same plant, the efficacy of different medicinal parts and the chemical components contained in it will be very different, such as ephedra and ephedra root, ephedra mainly contains ephedrine and pseudoephedrine , and Ephedra root is mainly macrospermine alkaloids. The research on the tung tree...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P35/00A61K127/00
CPCA61K36/185A61K2236/333A61K2236/51A61K2236/55
Inventor 侯小涛罗花邓家刚郝二伟杜正彩易湘西谢滟冯小慧谭德超
Owner GUANGXI UNIV OF CHINESE MEDICINE
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