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A human urine detection reagent for monohydric phenol metabolites

A technology of monohydric phenols and detection reagents is applied in the field of human urine detection reagents for monohydric phenol metabolites, which can solve the problems of complex composition, misdiagnosis, limited application value and the like.

Active Publication Date: 2019-03-08
浙江道家医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the complex composition of urine, certain trace components or abnormal metabolic products caused by other causes will also combine with mercury ions and mercury ions in the detection reagent to form color precipitates, which will seriously interfere with the accuracy of the test results and cause misdiagnosis. limit its application value
[0005] In addition, mercury ions and mercury ions in the detection reagent are affected by the environment and are easily hydrolyzed, so the storage time of the reagent is short and the stability is poor

Method used

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  • A human urine detection reagent for monohydric phenol metabolites
  • A human urine detection reagent for monohydric phenol metabolites
  • A human urine detection reagent for monohydric phenol metabolites

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preparation example Construction

[0034] In one embodiment, the preparation method of the described mercury ion mesoporous silica comprises the following steps:

[0035](1) Preparation of mesoporous silica: Add ethylene oxide-propylene oxide-ethylene oxide triblock copolymer and nitric acid into the reactor, and stir until the solid is completely dissolved at a temperature of 40°C. Add tetraethyl orthosilicate and sodium dodecylsulfonate dropwise to the solution, continue to react for 2 hours, then adjust the temperature to 70°C and react for 72 hours, soak the obtained gel in alcohol, stir and wash 3 times , filtered and dried in an oven at 100°C, and finally calcined the obtained sample in a muffle furnace at 550°C for 6 hours to remove the template agent to obtain mesoporous silica;

[0036] (2) Preparation of modified mesoporous silica: add mesoporous silica, toluene, 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyl to the reactor Disiloxane, mixed into a suspension, refluxed at 80°C for 12h, after the reaction...

Embodiment 1

[0052] The raw materials for the preparation of the monohydric phenol metabolite human urine detection reagent include mercuric sulfate solution, mercurous nitrate solution, nickel sulfate solution, silicotungstic acid solution, trichloroacetic acid solution, mercurous ion mesoporous silica, acetic acid / Sodium acetate buffer solution; the concentration of the mercuric sulfate solution is 2.1mol / L; the concentration of the mercurous nitrate solution is 0.3mol / L; the concentration of the nickel sulfate solution is 0.02mol / L; the silicotungstic acid The concentration of solution is 3.2mmol / L; The mass fraction of described mercury ion mesoporous silica is 4.5%; The concentration of described acetic acid / sodium acetate buffer solution is 3mol / L; Described silicotungstic acid solution and described The concentration ratio of trichloroacetic acid solution is 1:0.64;

[0053] A preparation method of a monohydric phenol metabolite human urine detection reagent, comprising the followi...

Embodiment 2

[0060] The raw materials for the preparation of the monohydric phenol metabolite human urine detection reagent include mercuric sulfate solution, mercurous nitrate solution, nickel sulfate solution, silicotungstic acid solution, trichloroacetic acid solution, mercurous ion mesoporous silica, acetic acid / Sodium acetate buffer solution; the concentration of the mercuric sulfate solution is 2.1mol / L; the concentration of the mercurous nitrate solution is 0.3mol / L; the concentration of the nickel sulfate solution is 0.02mol / L; the silicotungstic acid The concentration of solution is 3.2mmol / L; The mass fraction of described mercury ion mesoporous silica is 4.5%; The concentration of described acetic acid / sodium acetate buffer solution is 3mol / L; Described silicotungstic acid solution and described The concentration ratio of trichloroacetic acid solution is 1:0.5;

[0061] A preparation method of a monohydric phenol metabolite human urine detection reagent, comprising the followin...

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Abstract

The invention provides a human urine detection reagent for monohydroxyphenyl metabolites. The human urine detection reagent for the monohydroxyphenyl metabolites comprises mercury sulfate solution, mercury nitrate solution, nickel sulfate solution, silicotungstic acid solution, trichloroacetic acid solution and mercury ion (i) mesoporous silica. The concentration of the mercury sulfate solution is 0.7-3 mol / L; the concentration of the mercury nitrate solution is 0.1-0.6 mol / L; the concentration of the nickel sulfate solution is 0.01-0.05 mol / L; the concentration of the silicotungstic acid solution is 1.0-4.0 mmol / L; the concentration of the trichloroacetic acid solution is 0.6-5.0 mmol / L; the mass fraction of the mercury ion (i) mesoporous silica is 3-10%.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular, the invention relates to a human urine detection reagent for monohydric phenol metabolites. Background technique [0002] Cancer mortality ranks first among all diseases and is the number one killer of human health. It has become a major cause of threat to human life and health. Therefore, the prevention and treatment of cancer has become one of the priorities of global health strategies, and the key to treating cancer is Early detection, early diagnosis and early treatment. Various imaging detection techniques, such as X-ray, B-ultrasound, CT, and magnetic resonance, as important auxiliary diagnostic methods for tumors, usually cannot find small early tumors, and require special and expensive equipment investment, so there are limitations in application. Certain limitations, especially not suitable for large-scale tumor screening and use in grassroots units or remote a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/50C01B33/12
CPCC01B33/12G01N33/50
Inventor 胡振皖
Owner 浙江道家医疗科技有限公司
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