Application of giant molecular weight hyaluronic acid in naked mole rats in the preparation of breast cancer drugs
A technology of hyaluronic acid and naked mole rats, which can be used in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., and can solve problems such as serious physical damage
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specific Embodiment approach 1
[0028] Embodiment 1: The application of naked mole rat giant molecular weight hyaluronic acid in the preparation of drugs for treating breast cancer in this embodiment.
[0029] 4T1 and BT549 cells overexpressing the Has2 gene of naked mole rats can secrete hyaluronic acid with a huge molecular weight (molecular weight reaches 6MDa). In vitro experiments showed that giant molecular weight hyaluronic acid can significantly promote the apoptosis and inhibit proliferation of 4T1 and BT549 cells: the ratio of EdU-positive cells in the 4T1 overexpression naked mole rat Has2 genome and the addition of giant molecular weight HA group was 30-40% lower than that in the control group ;The ratio of EdU positive cells in BT549 overexpression of naked mole rat Has2 gene group and the addition of giant molecular weight HA group was about 20% lower than that of the control group, and the expression level of PCNAmRNA in the overexpression naked mole rat Has2 gene group and addition of giant mo...
specific Embodiment approach 2
[0030] Embodiment 2: This embodiment differs from Embodiment 1 in that: naked mole rat giant hyaluronic acid is used to promote the apoptosis of BT549 cells and inhibit the proliferation of BT549 cells. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0031] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that the giant molecular weight hyaluronic acid of naked mole rats is used to promote the apoptosis of 4T1 cells and inhibit the proliferation of 4T1 cells. Others are the same as those in Embodiment 1 or 2.
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