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Cell proliferation system for improving cell inoculation dispersity

A cell and cell reactor technology, applied in the field of cell expansion system, can solve the problems affecting the yield and effect of cell culture

Inactive Publication Date: 2017-08-15
奥凯(苏州)生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once cell contact inhibition occurs, it will greatly affect the yield and effect of cell culture

Method used

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  • Cell proliferation system for improving cell inoculation dispersity
  • Cell proliferation system for improving cell inoculation dispersity
  • Cell proliferation system for improving cell inoculation dispersity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as figure 2 As shown, the cell reactor 3 is connected to the output shaft of the drive motor 4 (not shown in the figure) through the fixed structure 6, and the drive motor 4 can drive the fixed structure 6 to rotate to drive the cell reactor 3 to rotate. During the growth process of the cells in the cell reactor 3, the fixed structure 6 can be driven to rotate by the driving motor 4 to drive the rotation of the cell reactor 3, which can disturb the nutrient solution and cells in the cell reactor 3, so that the cells in the reactor Distribute evenly to prevent contact inhibition of cells. At the same time, the rotation of the cell reactor 3 can promote full contact between the cells and the nutrient solution, which is more conducive to the growth of the cells.

[0033] It should be noted, figure 2 The driving motor 4 is not shown in the figure, and the driving motor 4 can be installed between the fixed structure 6 and the wall of the incubator 2, and can also be...

Embodiment 2

[0045] Such as image 3 As shown, the difference between this embodiment and Embodiment 1 is: the cell reactor 3 is a cylindrical structure, one end of the cell reactor 3 is connected to the output shaft of the drive motor 4, and the other end is rotatably connected to the incubator 2, and the drive The motor 4 can drive the cell reactor 3 to rotate around its central axis. During the growth of cells in the cell reactor 3, the drive motor 4 drives the cell reactor 3 to rotate around its central axis, which can disturb the nutrient solution and cells in the cell reactor 3, so that the cells are evenly distributed in the reactor, so as to Prevents contact inhibition of cells. In addition, when the cells are inoculated, the driving motor 4 drives the cell reactor 3 to rotate around its central axis, so that the inoculated cells can be evenly dispersed in the cell reactor 3, and the full contact between the cells and the nutrient solution is promoted to facilitate the growth of t...

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Abstract

The embodiment of the invention provides a cell proliferation system for improving the cell inoculation dispersity and relates to the technical field of cell culture. The cell proliferation system can enable cells to be uniformly distributed and prevent the cells from generating a contact inhibition phenomenon. The cell proliferation system for improving the cell inoculation dispersity comprises a nutrient solution supplying device and an incubator; a cell reactor and a drive motor are arranged in the incubator; the nutrient solution supplying device is communicated with the cell reactor to convey a nutrient solution into the cell reactor; the drive motor is fixedly connected with the incubator; the cell reactor is in transmission connection with the drive motor; and the drive motor can drive the cell reactor to rotate. The cell proliferation system is used for cell culture.

Description

technical field [0001] The invention relates to the technical field of cell culture, in particular to a cell expansion system for improving the dispersibility of cell seeding. Background technique [0002] Cell culture generally refers to all in vitro culture, which means to take out tissues from animals or human bodies, separate the tissues into single cells by mechanical methods or enzyme digestion methods, and let them be carried out under specific in vitro conditions such as simulating the physiological environment in vivo. Incubate the culture to allow it to survive and grow. In order to enable cells to grow smoothly, it is often necessary to detect the growth environment of cells during cell culture. [0003] The existing method of supplying nutrient solution for cell culture is generally as follows: cells are inoculated in the reactor through pipelines, and then the nutrient solution is provided for the cells or tissues through the delivery pipeline for their growth....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M3/06
CPCC12M27/10C12M23/48C12M25/10C12M29/00C12M41/14
Inventor 于净王维军周飞彪李朝辉曾亦达杨红磊
Owner 奥凯(苏州)生物技术有限公司
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