Preparation method and novel application of saponin of radix adenophorae
A technology of ginsenosides and ginseng, which is applied to the preparation of ginsenosides and the field of action in medicines, can solve the problems of not being listed, difficult to improve the quality of life, obvious liver toxicity and the like
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Embodiment 1
[0016] Example 1 : Preparation method of ginseng saponins for preventing and treating pulmonary hypertension:
[0017] Take 500g of Nansha ginseng medicinal material, wash and chop, add 50% ethanol and reflux for 3 times, reflux for 2 hours each time, and use 5L of solvent each time, combine the extracts, concentrate under reduced pressure, add water to stir and dilute, add to the treated 1kg HPD100 type macroporous adsorption resin column, wash with water until the collected solution is colorless, then elute with 50% ethanol until it is colorless or very light, combine the 50% ethanol eluents, concentrate and dry, and get Nansha ginseng saponins.
Embodiment 2
[0018] Example 2 : Effects of ginseng saponins on pulmonary arterial hypertension induced by lobectomy combined with monocrotaline in SD rats
[0019] 2.1. Experimental animals: SD rats, 3 months old, male, 200±20g, 48
[0020] 2.2 Experimental drugs and equipment: Nansha ginsenoside, monocrotaline (purchased from Sigma), chloral hydrate, urethane, pressure transducer and PowerLab physiological information collection and processing system
[0021] 2.3 Severe PAH model was established by lobectomy combined with monocrotaline (MCT) injection: the rats were weighed, anesthetized by intraperitoneal injection of 12% urethane (8ml / kg), tracheal intubation was performed with a 16G arteriovenous catheter, and Harvard breathing was connected. Machine (tidal volume 2ml; frequency, 80 times / min; PEEP1.0cmH20. The left fourth intercostal space was inserted into the chest, the left lung lobe was ligated and removed, and the rat lung lobe was 1 lobe on the left, 4 lobes on the right, an...
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