A kind of crude drug powder online detection device and detection method

A detection method and detection device technology are applied in the field of near-infrared detection to achieve the effects of accurate and reliable analysis results, simple operation and simple sampling.

Active Publication Date: 2022-03-29
JIUZHITANG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of these literatures are aimed at a single or a few index components in the finished products of Liuwei Dihuang Pills Concentrated Pills, and most of them use the partial least squares regression algorithm as the modeling method of the quantitative model, and use the reverse artificial neural network based on principal component analysis for Liuwei There are no relevant reports on the online detection of multiple quality control indicators in the crude drug powder of Dihuang Pill Xiaomi Pill

Method used

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  • A kind of crude drug powder online detection device and detection method
  • A kind of crude drug powder online detection device and detection method
  • A kind of crude drug powder online detection device and detection method

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Example 1 Online Device

[0044] See figure 1 , A pharmaceutical powder online detection device, including a mixer 1, a sampling conduit 2, a sampling switch 3, a sample table 4, a fiber probe 5, a near infrared spectrometer 6, and a control system 7. The sample table 4 is connected to the mixer 1 by the sampling tube 2, and the sampling switch 3 is used to control the collection sample; the sample table 4 is connected to the near-infrared spectrometer 6 through the fiber probe 5; the control system 7 is connected to the near infrared spectrometer 6, the mixer 1 is connected by a cable connection The near-infrared spectroscopy data of the sampling table 4 is collected by near-infrared spectrometer 6 and modeling, detection, analysis, and results determination and control. For better sampling, the online detecting device also has a sampling conduit port controller 8, disposed on the sampling conduit 2, and controls the port of the sampling tube 2 to sample different location...

Embodiment 2

[0047] The online detection method of the pharmaceutical powder with Liuwei Dihuang Pills Xiaomi Pills (combined with attached figure 1 ), Including the following steps:

[0048] (a) Configuration of online detecting device: Online detecting device includes a mixing machine 1, a sampling conduit 2, a sampling switch 3, a sample table 4, a fiber optic probe 5, a near infrared spectrometer 6, a control system 7, and a sample station 4 is obtained by sampling 2 The mixer 1 is connected, the sampling switch 3 is used to control the collection sample, and the sample table 4 is connected to the near infrared spectrometer 6 by the fiber probe 5, the control system 7 is connected to the near infrared spectrometer 6, and the mixer 1 is connected by the cable connection, and the sample is collected by near-infrared spectrometer 6 Near infrared spectroscopy data of Taiwan 4 and the modeling, detection, analysis, and results of results; for better sampling, the online detecting device also ha...

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Abstract

The present invention provides an online detection device and detection method for crude drug powder. The detection device includes a mixer, a sampling pipeline, a sampling switch, a sampling platform, an optical fiber probe, a near-infrared spectrometer, and a control system. The online detection method includes the following steps: (a) The establishment of an online detection device; (b) Collection of crude drug powders of different production batches; (c) Determination of quality control indicators in crude drug powders; (d) Collection of near-infrared spectral data of crude drug powders; (e) Near-infrared Spectral modeling band selection and spectral preprocessing; (f) establishment and evaluation of near-infrared spectral models; (g) fast online detection with the built model; (h) judgment and control of detection results. The on-line detection device and detection method provided by the invention are beneficial to rapid and accurate on-line monitoring of the quality of crude drug powder.

Description

Technical field [0001] The present invention belongs to the field of near-infrared detection, and more particularly to an online detecting device and detection method of halody powder. Background technique [0002] In the medium-completed pharmaceutical preparation, the mixing of the biotechnical powder is a key step, the homogeneity and content reaches the target value is two important assessment indicators for the mixing of the biopsy powder. During the actual production process, sampling trouble, traditional detection and analysis methods, and seriously affect production efficiency. And in the pulverization process, the active ingredient of some of the pharmaceutical powder is susceptible to the temperature of the volatile or structural change. In the pulverization process, the temperature increases the temperature of the machine in the pulverization process so that its component loss has no target value, resulting in unqualified drug powder. The timely operation of material w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359
CPCG01N21/359
Inventor 谷陟欣刘雪松朱丽吴永江黄胜金叶孙芬芳颜冬兰欧金秀
Owner JIUZHITANG
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