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Anti-candida polypeptide and use thereof and anti-candida medicine

A technology for Candida and Candida albicans, applied in the direction of antifungal agents, medical preparations containing active ingredients, peptides, etc., can solve the problems of cytotoxicity, achieve inhibition of Candida, low hemolysis rate of human red blood cells, and peptide structure simple effect

Active Publication Date: 2017-08-08
SHENZHEN RES INST THE CHINESE UNIV OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unfortunately, all antifungal agents are cytotoxic, more pronounced at higher concentrations, and mixed use is being hotly debated

Method used

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  • Anti-candida polypeptide and use thereof and anti-candida medicine
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  • Anti-candida polypeptide and use thereof and anti-candida medicine

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Embodiment Construction

[0023] The present invention will be further described below with reference to the accompanying drawings and in combination with preferred embodiments.

[0024] The present invention provides an anti-Candida polypeptide. In a specific embodiment, the amino acid sequence of the polypeptide comprises any one of the amino acid sequences shown in SEQ ID NO:1-SEQ ID NO:12. In a preferred embodiment, the amino acid sequence of the polypeptide may be any one of the amino acid sequences shown in SEQ ID NO: 1 to SEQ ID NO: 12. In some other preferred embodiments, the amino acid sequence of the polypeptide can also be based on any continuous amino acid sequence shown in SEQ ID NO: 1 to SEQ ID NO: 12, at the N-terminal and / or C The end is connected with at least one amino acid residue that does not affect its anti-Candida activity.

[0025] Hereinafter, a preferred embodiment in which the amino acid sequence of the polypeptide is selected from any one of the amino acid sequences in Tabl...

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Abstract

The present invention provides an anti-candida polypeptide and use thereof and an anti-candida medicine, and the amino acid sequence of the polypeptide comprises any amino acid sequence as shown in SEQIDNO:1 to SEQIDNO:12. Experiment shows that the polypeptide designed by the invention is simple in structure and has the function of inhibiting Candida, and the polypeptide has the advantages of low hemolysis rate of human red blood cells.

Description

technical field [0001] The invention relates to the field of antifungal drugs, in particular to an anti-candida polypeptide and its use, and anti-candida drugs. Background technique [0002] Candida spp is an opportunistic pathogen that exists in the oral cavity, gastrointestinal tract and vaginal mucosa of normal humans. In healthy people, Candida does not cause any infections, but in immunocompromised people, Candida can cause serious infections. In recent years, due to the increase of cancer patients and AIDS patients receiving chemotherapy, the population of immunocompromised population has been increasing, coupled with the wide application of invasive minimally invasive diagnosis and treatment and the increase of organ transplantation operations, the number of cases of candida infection has also increased year by year . Candida has also become one of the most common nosocomial infection pathogens, with high morbidity and mortality. [0003] The results of the survey ...

Claims

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Application Information

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IPC IPC(8): C07K7/08A61K38/10A61P31/10
CPCA61K38/00C07K7/08
Inventor 王灏吴子斌
Owner SHENZHEN RES INST THE CHINESE UNIV OF HONG KONG
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