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SNP mark for evaluating genetic background infiltration phenomenon of rhesus monkeys in cynomolgus monkeys and application of SNP mark

A technique for rhesus monkeys and cynomolgus monkeys, applied to SNP markers and its application fields for evaluating the genetic background introgression phenomenon of rhesus monkeys in cynomolgus monkeys, and can solve urgent problems

Inactive Publication Date: 2017-08-04
SOUTH CHINA UNIV OF TECH
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Problems solved by technology

However, compared with the current advanced molecular detection technology and the leading level of international counterparts, my country's genetic monitoring standards still need to be improved, and it is urgent

Method used

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  • SNP mark for evaluating genetic background infiltration phenomenon of rhesus monkeys in cynomolgus monkeys and application of SNP mark
  • SNP mark for evaluating genetic background infiltration phenomenon of rhesus monkeys in cynomolgus monkeys and application of SNP mark
  • SNP mark for evaluating genetic background infiltration phenomenon of rhesus monkeys in cynomolgus monkeys and application of SNP mark

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Embodiment 1

[0069] 1. Experimental animal samples

[0070] 25 cynomolgus monkeys from 5 different geographic regions [Cambodia, Zamboanga (Mindanao, Philippines), South Sumatra (Palembang, Indonesia), Mauritius and Malaysia]; 390 cynomolgus monkeys of Indochina origin; 58 1 Chinese rhesus monkey; 37 Malaysian / Indonesian cynomolgus monkeys.

[0071] 2. Source of animal blood samples: Landao Biotechnology Co., Ltd.

[0072] 3. SNP screening process

[0073] First, 23,000 existing SNPs co-existing in Indian and Chinese rhesus monkeys were screened, and 384 SNPs with the highest frequency were screened out using bioinformatics methods.

[0074] Then, the 384 most frequent SNPs shared by Indian and Chinese rhesus monkeys were genotyped from 5 different geographic regions [Cambodia, Zamboanga (Mindanao, Philippines), South Sumatra (Palembang, Indonesia), 25 cynomolgus monkeys in Mauritius and Malaysia], and then we selected 48 SNPs with the highest frequency and only existed in cynomolgus mo...

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Abstract

The invention discloses an SNP mark for evaluating a genetic background infiltration phenomenon of rhesus monkeys in cynomolgus monkeys and application of the SNP mark. The SNP mark comprises 48 SNP loci, namely SNP1-SNP48 which are respectively located at loci 151 in nucleotide sequences represented by SEQ ID NO:1-SEQ ID:NO48. By utilizing advantages of biological information techniques, the SNP mark for evaluating the genetic background infiltration phenomenon of the rhesus monkeys in the cynomolgus monkeys is developed and is applied to the evaluation of a genetic background infiltration level of the rhesus monkeys in the cynomolgus monkeys, so that the cost is greatly lowered, and the operation is simplified. By applying the SNP mark, rapid preliminary screening can be realized, the detection cost is lowered, and therefore, the standardized process of the evaluation of the genetic background infiltration phenomenon of the rhesus monkeys in the cynomolgus monkeys is promoted.

Description

technical field [0001] The present invention relates to the advantage of utilizing genome biological information analysis technology, in particular to a SNP marker and its application for evaluating the genetic background introgression phenomenon of rhesus monkeys in cynomolgus monkeys; 48 SNP markers are screened out for use in cynomolgus monkeys Evaluation of the phenomenon of genetic background introgression in rhesus monkeys. Background technique [0002] At present, the domestic biomedical industry is developing rapidly. As an important supporting condition for the biomedical industry and an important material for life science research, experimental animals are directly related to the reliability and authenticity of experimental results. The genetic quality of experimental animals is one of the important factors for the quality of experimental animals. Only the use of experimental animals with stable genetic characteristics can ensure the comparability of biomedical res...

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6888C12Q2600/156
Inventor 杜红丽蒙裕欢曾玉琳
Owner SOUTH CHINA UNIV OF TECH
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