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Compound caulophyllum robustum composition, and preparation method and application thereof

A kind of technology of peony leaf and composition, which is applied in the field of new traditional Chinese medicine to achieve the effect of improving curative effect and reducing side effects

Inactive Publication Date: 2017-06-20
匡海学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The compound leaf tree composition involved in this patent includes the active ingredient extracts of the three herbs of leaf tree, white peony root and ephedra. The three are compatible for the treatment of rheumatoid arthritis, and no related reports have been seen yet.

Method used

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  • Compound caulophyllum robustum composition, and preparation method and application thereof
  • Compound caulophyllum robustum composition, and preparation method and application thereof
  • Compound caulophyllum robustum composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preparation of compound leaf peony composition

[0016] Paeonia fructus medicinal material, pulverized, refluxed with 60% ethanol for 3 times, each time for 2 hours, combined the extracts, recovered the solvent to obtain the peony leaf extract, suspended in water and then carried out macroporous adsorption resin column chromatography, first washed with distilled water Then use 50% ethanol gradient elution, collect 8 times column volume of 20% ethanol eluate, collect 6 times column volume of 0% ethanol eluate, collect 6 times column volume of 70% ethanol eluate, combine elution liquid, and recovered under reduced pressure to obtain the leaf peony extract. The extract is suspended in water and then subjected to macroporous adsorption resin column chromatography, first eluted with distilled water, then gradient eluted with 50% ethanol, collecting 8 times the column volume of the 50% ethanol eluate, and collecting 60% ethanol eluate 8 times the column volume, co...

Embodiment 2

[0019] Embodiment two: the preparation of the compound tablet of leaf peony composition

[0020]

[0021] Mix the above components evenly, add appropriate amount of talcum powder, and press into tablets.

Embodiment 3

[0022] Example 3: Preparation of compound capsules of leaf peony composition

[0023]

[0024] The above components are mixed evenly, granulated by 80-mesh sieve, granulated by 60-mesh sieve, and filled into capsules.

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PUM

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Abstract

The invention relates to a caulophyllum robustum composition, and a preparation method and pharmacy application thereof. The preparation method of the composition comprises the steps of after extracting caulophyllum robustum, carrying out macroreticular resin adsorption; after washing and cleaning, carrying out gradient elution on ethyl alcohol; after recovering the ethyl alcohol, obtaining a caulophyllum robustum effective ingredient extract, wherein the contents of caulophyllum robustum iconic effective ingredients such as caulosaponin C and caulosaponin G can reach to 20 percent or more by weight of the extract; carrying out water extraction, concentration and drying on herba ephedra and radix paeoniae alba to obtain fine powder. The two extracts are composed according to appropriate proportion, and pharmaceutically acceptable auxiliary materials are added to prepare a medicinal liquor, tincture, a capsule, a tablet, granules, pills, an oral liquid and other oral preparations. The composition provided by the invention has an effect on treating chronic infectious arthritis, and is used for treating and preventing various pains, inflammatory injury, joint injury and the like. The caulophyllum robustum composition provided by the invention selects natural vegetable drugs as raw materials, has an obvious effect when being used for treating chronic infectious arthritis, is poisonless and harmless to a human body, and meets the national drug administration laws and regulations.

Description

technical field [0001] The invention relates to a compound botan-like composition, in particular to a compound botan-like composition for treating rheumatoid arthritis, as well as a preparation method and application of the composition. The composition is composed of peony phylloides, peony root and ephedra, and belongs to the technical field of new traditional Chinese medicines. The compound preparation has good curative effect on treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoidarthritis, RA) is a multisystem inflammatory autoimmune disease mainly involving peripheral joints. It mainly affects the synovium of the joints, and can later spread to the articular cartilage, bone tissue, joint ligaments and tendons, followed by connective tissues such as serosa, heart, lungs and eyes. The pathological features are synovial inflammation, cell proliferation, granuloma formation, and cartilage destruction, which usually lead to irrevers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61P19/02A61P29/00
Inventor 吕邵娃薛娟郭玉岩王知斌苏晓琳匡海学
Owner 匡海学
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