Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A pharmaceutical composition for preventing and treating diarrhea in weaned piglets and its preparation method and application

A technology for weaning piglet diarrhea and composition, which is applied in the field of pharmaceutical composition for preventing and treating weaning piglet diarrhea and its preparation, which can solve the problems of short half-life, large side effects, inconvenient use, etc., and achieve the promotion of body immune function, low cost, and convenient material selection Effect

Active Publication Date: 2021-06-04
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
View PDF17 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since piglet diarrhea usually occurs in piglets after weaning (28 days of age), farmers are more inclined to use drugs with strong pertinence, high bioavailability and strong safety within the susceptible age, through convenient oral administration Prevention and treatment by means of vaccination, so as to make up for the shortcomings of vaccine injection, such as inconvenient use, large side effects, complicated process, short half-life, and inconvenient storage.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A pharmaceutical composition for preventing and treating diarrhea in weaned piglets and its preparation method and application
  • A pharmaceutical composition for preventing and treating diarrhea in weaned piglets and its preparation method and application
  • A pharmaceutical composition for preventing and treating diarrhea in weaned piglets and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 specific anti E. Coli -IgY, anti-TGE-PED-PoRV-IgY egg yolk antibody and preparation of corresponding egg yolk powder

[0046] (1) Preparation of different types of highly immunogenic immune antigens and immunization schemes

[0047] ① The immunogen is Escherichia coli bacterial protein antigen immune substance

[0048] Select Escherichia coli ( E. coli, O157:K88, CVCC1489, purchased from China Veterinary Microbiological Culture Collection Management Center). The culture of the main pathogenic bacteria is preferably subcultured on blood agar slant medium, cultivated at 37 °C for 24 hours, and there is no miscellaneous bacteria under the staining microscope to obtain pure species. The main pathogenic bacteria were inoculated in LB broth medium (containing 5-10% calf serum and 1-2% glucose) for expansion culture, and placed in a constant temperature shaking incubator at 37 ℃ (150-200 r / min ), cultured for 24 h, and the bacterial cells were collected by c...

Embodiment 2

[0058] Example 2 The preparation of probiotic yeast dry powder, the steps are as follows:

[0059] (1) Preparation of medium:

[0060] Liquid medium: the composition includes glucose 50 g·L -1 , yeast extract 2.0 g L -1 , Wort 120 mL / L, MgSO 4 0.5 g L -1 , FeSO 4 0.1g L -1 , urea 1.0 g·L -1 . Adjust the pH to 6.0, sterilize at 121°C for 30 min, dispense into Erlenmeyer flasks, and set aside.

[0061] Slant and plate medium (g L -1 ): Ingredients include glucose 50 g·L -1 , yeast extract 2.0 g L -1 , Wort 120 mL / L, MgSO 4 0.5 g L -1 , FeSO 4 0.1g L -1 , urea 1.0 g·L -1 , agar 20 g·L -1 . Adjust the pH to 6.0, sterilize at 121°C for 20 min, pour into the plate, and set aside.

[0062] (2) Yeast culture:

[0063] Saccharomyces cerevisiae( Saccharomyces cerevisiae , purchased from China Veterinary Microbiological Strain Preservation Management Center, feed yeast, strain number 2.1011), pick out a ring of relatively plump yeast lawn from the slant storage seed, ...

Embodiment 3

[0067] Example 3 The preparation method of the dry powder of the compound Chinese medicine extract, wherein the proportioning ratio of each single Chinese medicine is as follows:

[0068] The traditional Chinese medicine composition consists of the following components in parts by weight:

[0069] 10-30 parts of Sophora flavescens, 10-30 parts of Burnet, 10-20 parts of Coptidis, 10-20 parts of Phellodendron 10-20, 10-20 parts of gall, 10-20 parts of dandelion, 10-20 parts of Dijincao, 5 parts of Houttuynia cordata -15 parts, 5-15 parts of agrimony, 5-15 parts of purslane, 5-15 parts of plantain, 2-15 parts of barley, 2-15 parts of yarrow, 5-15 parts of licorice.

[0070] The preparation method of Chinese medicine compound extract dry powder is:

[0071] (1) Pulverize each single traditional Chinese medicine through a superfine powder pulverizer, and pass through a 100-120 mesh sieve;

[0072] (2) Formulate and mix the superfine powder single-flavor Chinese medicines obtained...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a pharmaceutical composition for preventing and treating diarrhea in weaned piglets, the pharmaceutical composition is composed of the following components: anti- E. Coli ‑IgY egg yolk antibody dry powder, anti-TGE‑PED‑PoRV‑IgY egg yolk antibody dry powder, traditional Chinese medicine compound extract dry powder, egg yolk powder and probiotic yeast dry powder. The invention also provides its preparation method and its application in the preparation of medicine for preventing and treating diarrhea of ​​weaned piglets. The pharmaceutical composition of the invention can be used as a high-quality medicine and feed additive for preventing and treating diarrhea of ​​weaned piglets, and has certain development and application value. The preparation method of the invention has the advantages of convenient material selection, high extraction efficiency, relatively low cost and easy formation of large-scale production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine and relates to a medicine for preventing and treating diarrhea of ​​piglets, in particular to a pharmaceutical composition for preventing and treating diarrhea of ​​weaned piglets, a preparation method and application thereof. Background technique [0002] Piglet diarrhea is a typical multifactorial disease. There are many kinds of pathogens causing piglet diarrhea, the disease nature is complex, and it is often mixed with multiple pathogens. Piglet diarrhea has been an important cause of growth retardation and high mortality of piglets for a long time, and the prevention and treatment of piglet diarrhea has always been an eye-catching worldwide problem. The causes of piglet diarrhea can be classified into two categories: non-infectious diarrhea and infectious diarrhea. Piglet non-infectious diarrhea often occurs due to piglet digestive insufficiency, dietary antigen allergy, lack of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61P1/12A23K50/30A23K10/30A23K10/20A23K20/147A61K35/64A61K36/78A61K35/57
CPCA61K35/57A61K36/064A61K36/185A61K36/28A61K36/288A61K36/47A61K36/484A61K36/489A61K36/68A61K36/70A61K36/718A61K36/73A61K36/739A61K36/756A61K36/78A61K39/39533A61K2236/331A61K2236/39A61K2236/51A61K35/63A61K2300/00
Inventor 王玲刘宇杨峰魏小娟郭文柱罗永江张彬杨珍周绪正罗金印牛建荣郭爱民
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com