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Fracture healing simulation method based on cell activity

A fracture healing and simulation method technology, applied in the field of biomedical engineering, can solve the problems that mechanical factors do not have a deterministic relationship with cell differentiation, do not consider cell proliferation, differentiation and apoptosis, and the setting of fracture healing areas is too simplified, so as to avoid Humanitarian controversies, effects on reducing delayed union and improving fracture healing quality

Inactive Publication Date: 2017-05-31
HARBIN UNIV OF SCI & TECH
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. There is no individualized model specifically for patients;
[0005] 2. There is no definite relationship between mechanical factors and cell differentiation;
[0006] 3. The simulation method only considers the tissue level, and does not consider the activities of cell proliferation, differentiation and apoptosis;
[0007] 4. The model and biological material settings of the fracture healing area are too simplified

Method used

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  • Fracture healing simulation method based on cell activity
  • Fracture healing simulation method based on cell activity
  • Fracture healing simulation method based on cell activity

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specific Embodiment approach 1

[0026] Specific embodiment 1: a kind of fracture healing simulation method based on cell activity comprises the following steps:

[0027] Step 1: Establish a three-dimensional geometric model of the fracture area;

[0028] Step 2: Mesh the 3D geometric model established in Step 1 to obtain a finite element model of the fracture area;

[0029] Step 3: Obtain the material properties and cell concentration of the fracture area unit;

[0030] Step 4: Finite element analysis of the fracture area, solving the octahedral shear strain and flow velocity suffered by the fracture area units;

[0031] Step 5: Solve the mechanical stimulation of the fracture area unit, and obtain a new tissue phenotype according to the force adjustment algorithm;

[0032] Step 6: Analyze cell activity;

[0033] Step 7: Calculate the material properties of the new fracture area elements;

[0034] Step 8: Determine whether the program meets the termination condition. If not, the program enters the next i...

specific Embodiment approach 2

[0036] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the establishment of the three-dimensional geometric model of the fracture area in the step one is specifically:

[0037] Using the segmentation-based 3D medical image surface reconstruction algorithm to reconstruct the 3D surface of the image to obtain a 3D geometric model;

[0038] The image is obtained by imaging equipment CT, and the data storage format is DICOM;

[0039] The process of constructing the solid model from the surface model is to construct the surface list of the solid model from the triangular slice sequence of the surface model and the upper and lower bottom surfaces, and construct the vertex list of the solid model from the vertex sequence of the surface model, and simultaneously establish the body, ring, edge and half edge The linked list and the pointing relationship of the nodes in each linked list. The solid construction process expressed by the boun...

specific Embodiment approach 3

[0041] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the step two adopts octahedral mesh division unit to divide the three-dimensional geometric model into a grid, and the specific process of obtaining the finite element model of the fracture area is as follows:

[0042] Import the three-dimensional geometric model established in the specific embodiment one into the mesh division software, perform mesh division, and obtain the finite element model of the fracture area;

[0043] A lot of data will be obtained after meshing by meshing software, but in the present invention, only node coordinates and element numbers are needed to represent the finite element model of the fracture healing area, so it is necessary to import the obtained data into MATLAB for preprocessing, and only extract Target data, according to the target data, two files of unit number and node coordinates required for subsequent finite element calculatio...

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Abstract

A fracture healing simulation method based on cell activity relates to the field of biomedical engineering and is used for predicting a complex process of fracture healing and seeking an optimal fracture healing scheme. The method comprises the steps of I, establishing a three-dimensional geometric model of a fracture region; II, establishing a fracture healing region finite element model; III, acquiring material attribute and cell concentration of a fracture region unit; IV, subjecting the fracture region to finite element analysis; V, solving mechanical stimulus borne by the fracture region unit, and acquiring new tissue phenotype according to force regulating algorithm; VI, analyzing cell activity; VII, calculating material attribute of a new fracture healing region unit; VIII, judging whether the program ends or not. Through the fracture healing simulation method based on cell activity, it is possible to simulate a fracture healing process more precisely, and doctors are helped to make an optimal fracture healing surgical scheme.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a fracture healing simulation method based on cell activity. Background technique [0002] Fracture is a common trauma, and the high incidence of fracture makes the study of fracture mechanism and promotion of healing extremely urgent. Different from other tissue injury repairs, fractures are not connected by fibrous connective tissue, but complete regeneration of bone tissue. However, not all fractures heal completely and sometimes delayed union or even nonunion occurs. Delayed union or nonunion of fractures can cause pain and dysfunction in the affected limb, leading to unemployment of the patient, which causes a great social and economic burden. Therefore, although the research on fracture healing has been receiving much attention, there are still 5% to 10% of fractures with delayed union or even nonunion due to various reasons. [0003] The process of fracture healing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F17/50
CPCG06F30/23
Inventor 王沫楠杨宁王新宇
Owner HARBIN UNIV OF SCI & TECH
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