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Process system and method for preparing carnosine

A process system and carnosine technology, applied in the field of preparing carnosine, can solve the problems of high solvent consumption, unfavorable industrialization, environmental pollution, etc., and achieve the effects of high reaction generation rate, favorable industrialization, and low energy consumption

Pending Publication Date: 2017-05-24
JIANGSU CHENGXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The yield of this route is low, and it is easy to racemize in the formation of peptide bonds, which affects the purity, and the solvent consumption is too high, which is easy to cause environmental pollution. In addition, the route is long, which is not conducive to industrialization

Method used

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  • Process system and method for preparing carnosine

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Experimental program
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Effect test

Embodiment 1

[0025] Such as figure 1 , a process system for preparing carnosine, comprising a first reactor (1), a second reactor (2), a first centrifuge (3), ultrafiltration equipment (5), nanofiltration equipment (6), crystallization tank (7), second centrifuge (8); also includes methanol storage tank (9), thionyl chloride storage tank (10), β-alanine storage tank (11), the methanol storage tank (9 ), the thionyl chloride storage tank (10), and the β-alanine storage tank (11) are located upstream of the first reaction kettle (1), and are respectively connected to the first reaction kettle (1) by pipelines; Including L-histidine storage tank (12), deionized water storage tank (13), alkaline solution storage tank (14); said L-histidine storage tank (12), deionized water storage tank (13 ), the alkaline solution storage tank (14) is located upstream of the second reaction kettle (2), and is connected to the second reaction kettle (2) respectively; A tank (4), the β-alanine methyl ester hy...

Embodiment 2

[0038] Embodiment 2: Synthesis of β-alanine methyl ester hydrochloride

[0039] 1. Accurately weigh 400g of methanol and 220g of thionyl chloride, control the temperature at 0-5°C, slowly add thionyl chloride into methanol dropwise, after the addition is complete, add 160g of β-alanine, and keep warm at 30-35°C Stir for 2h;

[0040] 2. At the end of the heat preservation, depressurize at 35-40°C, vacuum degree ≤ -0.09MPa, concentrate until no fraction flows out, and obtain 245g of β-alanine methyl ester hydrochloride;

[0041] 3. Add 20g of L-histidine, 400g of deionized water, and 25g of β-alanine methyl ester hydrochloride into the reaction bottle, and stir evenly;

[0042] 4. At 25-30°C, adjust the pH to 7.0-7.5 with 30% sodium hydroxide;

[0043] 5. Stir and react at 25-30°C for 4.0 hours. During the reaction, use 5% NaOH solution to control the pH value of the reaction system at 7.0-7.5.

[0044] 6. After the reaction is completed, the content of carnosine in the react...

Embodiment 3

[0048] Embodiment 3: Enzyme reaction embodiment

[0049] 1. Accurately weigh 500g of methanol and 280g of thionyl chloride, control the temperature at 10-15°C, slowly add thionyl chloride into methanol dropwise, after the addition is complete, add 200g of β-alanine, and keep warm at 35-40°C Stir for 4h;

[0050]2. At the end of the heat preservation, depressurize at 45-50°C, vacuum degree ≤ -0.09MPa, concentrate until no fraction flows out, and obtain 307g of β-alanine methyl ester hydrochloride;

[0051] 3. Add 30g of L-histidine, 600g of deionized water, and 37.5g of β-alanine methyl ester hydrochloride into the reaction bottle, and stir evenly;

[0052] 4. At 20-25°C, adjust the pH to 7.5-8.0 with 20% ammonia water;

[0053] 5. Stir and react at 20-25°C for 3.0 hours. During the reaction, use 20% ammonia solution to control the pH value of the reaction system at 7.5-8.0.

[0054] 6. After the reaction is completed, the content of carnosine in the reaction solution is 6.3...

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Abstract

The invention relates to a process system for preparing carnosine. The process system comprises a first reaction kettle (1), a second reaction kettle (2), a first centrifugal machine (3), an ultrafiltration device (5), a nanofiltration device (6), a crystallization tank (7), a second centrifugal machine (8) and is characterized by further comprising a methanol storage tank (9), a sulfoxide chloride storage tank (10) and a beta-alanine storage tank (11), wherein the methanol storage tank (9), the sulfoxide chloride storage tank (10) and the beta-alanine storage tank (11) are located at the upstream of the first reaction kettle (1) and are in pipeline connection with the first reaction kettle (1) respectively. The process system is applied to process preparation of carnosine.

Description

technical field [0001] The invention relates to a chemical process, in particular to a process device and a process method for preparing carnosine. Background technique [0002] Carnosine is a dipeptide (ß-Ala-L-His) composed of ß-alanine and L-histidine. Carnosine has anti-oxidation, anti-free radical and anti-aging effects, so carnosine is used in the field of beauty and health care products. In recent years, studies have shown that carnosine has a therapeutic effect on early senile cataracts, immature cataracts, and other concurrent cataracts (the effective rate is more than 80%). At the same time, there is no case of adverse reactions in the observed medical records. In addition, eye drops containing carnosine can significantly improve vision loss with age (presbyopia) and reduce visual fatigue. Carnosine is used in food additives and tonics abroad. [0003] The commonly used synthesis process for preparing carnosine is to react ß-alanine with phthalic anhydride to gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/64
CPCC07D233/64
Inventor 刘家生祝俊吴锋王子坤刘双喜许刘华王峰峰许昇何宝亮邢飞
Owner JIANGSU CHENGXIN PHARMA
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