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Diagnosis of neuromyelitis optica vs. multiple sclerosis using mirna biomarkers

A technology for neuromyelitis optica and multiple sclerosis, applied in the field of diagnosis of neuromyelitis optica, can solve unmet problems

Inactive Publication Date: 2017-05-10
SIEMENS AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Therefore, there is an unmet need for an effective, simple, and reliable diagnostic test for NMO, especially one that can differentiate NMO from MS

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  • Diagnosis of neuromyelitis optica vs. multiple sclerosis using mirna biomarkers
  • Diagnosis of neuromyelitis optica vs. multiple sclerosis using mirna biomarkers
  • Diagnosis of neuromyelitis optica vs. multiple sclerosis using mirna biomarkers

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Embodiment Construction

[0109] Additional details, features, characteristics and advantages of the objects of the invention are further disclosed in the following description of the corresponding embodiments, which illustrate by way of example preferred embodiments of the invention, and the accompanying drawings. However, these examples should in no way be construed as limiting the scope of the present invention.

[0110] The present invention relates to methods for the differential diagnosis of neuromyelitis optica (NMO) and multiple sclerosis (MS) using miRNA biomarkers.

[0111] The diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during pre-existing neurological deficits that may be associated with inflammatory demyelination. In particular, it is difficult to differentiate NMO from MS (including CIS / RRMS), which usually presents the earliest stages of the disease. However, it is particularly desirable to have reliable diagnostic tests for this d...

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Abstract

The invention relates to a method of diagnosis of neuromyelitis optica, in particular of differential diagnosis of neuromyelitis optica (NMO) vs. multiple sclerosis (MS) using miRNA biomarkers. These miRNAs could potentially serve as future diagnostic biomarkers for NMO and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.

Description

technical field [0001] The present invention relates to a method for diagnosing neuromyelitis optica, particularly a method for differential diagnosis of neuromyelitis optica (NMO) and multiple sclerosis (MS) using miRNA markers. Background technique [0002] Recently, molecular diagnostics have gained increasing importance. Molecular diagnostics has found its way into the clinical diagnosis of disease (especially detection of infectious agents, detection of genomic mutations, detection of diseased cells, and identification of risk factors for disease susceptibility). [0003] In particular, nucleic acid analysis presents very promising new possibilities in disease research and diagnosis by measuring gene expression in tissues. [0004] Nucleic acids of interest to be detected include genomic DNA, expressed mRNA, and other RNAs, such as microRNAs (abbreviated as miRNAs). miRNAs are a new class of small RNAs with diverse biological functions (A. Keller et al., Nat Methods. ...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/118C12Q2600/158C12Q2600/178C12Q2600/16
Inventor A·凯勒J·基尔斯滕C·F·施特勒尔C·巴克斯P·雷丁格E·梅塞
Owner SIEMENS AG
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