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Core-shell magnetic composite particle coated with phosphorylcholine-containing polymer and preparation method thereof

A technology of magnetic composite particles and phosphorylcholine, which is applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, medical preparations with non-active ingredients, etc., to achieve good biocompatibility and clear preparation methods Simple and efficient, good in vivo degradability effect

Active Publication Date: 2020-05-12
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, phosphorylcholine, as a substance with a similar cell membrane structure, is an excellent anti-protein adsorption substance, and is also widely used as a modification of carrier materials (Shao, Q. and Jiang, S. Y.*, Adv. Mater. 2015, 27, 15–26) So far, there is no report about its direct use as a polymer shell to coat inorganic nanoparticles

Method used

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  • Core-shell magnetic composite particle coated with phosphorylcholine-containing polymer and preparation method thereof
  • Core-shell magnetic composite particle coated with phosphorylcholine-containing polymer and preparation method thereof
  • Core-shell magnetic composite particle coated with phosphorylcholine-containing polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Core-shell Fe with a shell thickness of about 150 nm, using BACy as a cross-linking agent and a cross-linking degree of 15% 3 O 4 Preparation of @PMPC Composite Particles

[0032] 1. Preparation of Citric Acid Stabilized Magnetic Clusters

[0033] 4.32g of ferric chloride hexahydrate (FeCl 3 6H2O), 4.8g sodium acetate (NaOAc), 1g sodium citrate were ultrasonically dissolved in 80ml ethylene glycol, then added to a 150ml three-necked flask, heated to 165°C, mechanically stirred, and incubated for 1.5h. The liquid was quickly transferred to a 100ml high-pressure reaction kettle containing a polytetrafluoroethylene lining, and then the reaction kettle was placed in an oven at 200°C for 22 hours of reaction, taken out, and cooled to room temperature with tap water. The product is separated by magnetic separation, and the unreacted reactants are removed by alternately washing with absolute ethanol and distilled water, and finally the product is freeze-dried for...

Embodiment 2

[0036] Example 2: Core-shell Fe with a shell thickness of about 100 nm, using BACy as a cross-linking agent and a cross-linking degree of 8% 3 O 4 Preparation of @PMPC composite particles 1. The preparation of citric acid-stabilized magnetic clusters is the same as described in Example 1-1;

[0037] 2. Fe 3 O 4 The @PMPC composite particles were prepared as described in Examples 1-2. The difference is that the amount of cross-linking agent BACy is 8.8 mg.

Embodiment 3

[0038] Example 3: Core-shell Fe with a shell thickness of about 50 nm, using BACy as a cross-linking agent and a cross-linking degree of 8% 3 O 4 Preparation of @PMPC Particles

[0039] 1. The preparation of citric acid-stabilized magnetic clusters is the same as described in Example 1-1;

[0040] 2. Fe 3 O 4 The @PMPC composite particles were prepared as described in Examples 1-2. The difference is that the dosages of 2-methacryloyloxyethylphosphorylcholine, BACy, and 2,2-azobisisobutyronitrile are 50 mg, 3.5 mg, and 0.7 mg, respectively.

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Abstract

The invention belongs to the technical fields of a magnetic composite material and a medicine, and specifically relates to core-shell magnetic composite particles coated with phosphorylcholine-containing polymer and a preparation method of the core-shell magnetic composite particles. In the core-shell magnetic composite particles, the core layers are magnetic ferroferric oxide nanoparticle clusters and the shell layers are cross-linked phosphorylcholine-containing polymer networks. The preparation method comprises: preparing sodium citrate stable magnetic clusters, and coating surfaces of the clusters with phosphorylcholine-containing polymer shell layers through a reflux precipitation polymerization method to obtain monodispersed core-shell magnetic composite particles. The particles can be used for subsequent loading of a photosensitizer, such as Ce6 and 5-aminolevulinic acid (5-ALA) and antitumor drugs, such as paclitaxel, doxorubicin, SN38 and cisplatin, so that the particles can be used for the field of cancer treatment. The thickness and crosslinking degree of the shell layers can be accurately controlled. The particles have redox stimulative responsibility, are good in biocompatibility and in-vivo degradability, and are ideal loading materials used in the living body.

Description

technical field [0001] The invention belongs to the technical field of magnetic composite materials and medicine, and particularly relates to a magnetic composite particle with redox responsiveness and a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT) is an effective tumor treatment method that has emerged in recent years, and has broad development prospects. The three elements of photodynamic therapy are photosensitizer, oxygen and laser light source. First, the photosensitizer is enriched in the tumor tissue, and then the photosensitizer at the tumor tissue is excited by irradiation with a specific wavelength of laser light, and then the excited state photosensitizer transfers energy to the surrounding oxygen to generate reactive oxygen species (ROS) to generate cells. Toxicity, which in turn leads to cell apoptosis. [0003] According to a large number of studies, Ce6 is a very effective photosensitizer, but due to it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K47/32A61K45/00A61K41/00A61P35/00C08F220/36C08F222/38
CPCA61K41/0061A61K41/0071A61K45/00A61K47/02A61K47/32C08F220/36C08F222/385
Inventor 丁雨雪张子豪汪长春
Owner FUDAN UNIV
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