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Acoustophoretic device with uniform fluid flow

An acoustic electrophoresis and fluid technology, which is applied in the fields of electricity/wave energy treatment of enzymes, electricity/wave energy treatment of microorganisms, separation methods, etc., which can solve the problems that fluid flow cannot capture different types of materials and does not allow continuous operation

Active Publication Date: 2017-03-22
FLODESIGN SONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This does not allow continuous operation
In addition, the power required to generate acoustic planar standing waves is easily heated by waste energy in the primary fluid
[0006] As a result, existing acoustoelectrophoretic devices have limited efficacy due to several factors including heat generation, restrictions on fluid flow, and inability to capture different types of materials

Method used

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  • Acoustophoretic device with uniform fluid flow
  • Acoustophoretic device with uniform fluid flow
  • Acoustophoretic device with uniform fluid flow

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example

[0144] Three different devices were fabricated and tested for their cell isolation efficiency. reference device with Figure 20 Similarly, with a single burst diffuser on one side. Second, use the same Figure 17 A similar device (abbreviated 2DD30) with two burst diffusers and shallow walls at an angle of 30 degrees. Third, use the same Figure 17 A similar device (abbreviated 2DD45) with two burst diffusers and shallow walls at an angle of 45 degrees.

[0145] The device was tested using a 1.5% by volume yeast solution. Each unit uses two transducers (arranged vertically one on top of the other), the top transducer is powered at 50 volts and the bottom transducer is at 60 volts, the two transducers are in Operates at a transducer frequency of 2.23MHz. The flow rate is about 270 mL / min, and the concentrate is discharged at a flow rate of about 8.1 mL / min. Cell separation efficiency was measured as the percent reduction in turbidity between influent and permeate. Table...

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Abstract

An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles / secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 020,088, filed July 2, 2014, and U.S. Provisional Patent Application No. 62 / 154,672, filed April 29, 2015, the full disclosure of which is Incorporated herein by reference. Background technique [0003] The ability to separate particle / fluid mixtures into individual components is desired in many applications. Physical size exclusion filters can be used for this purpose, where particles are captured on the filter and fluid flows through the filter. Examples of physical filters include those operated by tangential flow filtration, depth flow filtration, hollow fiber filtration, and centrifugation. However, physical filters can be complex. When the filter is full, the filtering capacity is reduced. Additionally, the use of such filters requires periodic stops to remove the filter and capture or clear particles trapped on the filter. [0004]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N13/00
CPCB01D21/0045B01D21/283
Inventor 巴特·利普肯斯布莱恩·麦卡西杰森·巴恩斯戴恩·米利本·罗斯-约翰斯路德沃尔特·M·小普雷斯凯达尔·奇塔莱
Owner FLODESIGN SONICS
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