Implantable closed-loop deep brain stimulation system

Abstract

The invention provides a fully implanted closed-loop brain deep simulating system based on brain deep electric signal sleep detection. The system utilizes a brain deep electric stimulator electrode for sensing an electrocardiosignal and a brain deep electric signal at a stimulating target point. The system extracts time domain, frequency domain and complexity analysis characteristics and further realizes detection and judgment on a sleep state by means of a classification algorithm, thereby adjusting the switching state and the output parameter of the stimulator and realizing closed-loop nerve stimulation in the sleep state. The implanted closed-loop brain deep simulating system provided by the invention has advantages of reducing side effects of brain deep electric stimulation and saving electric energy of a battery.

Description

technical field [0001] The invention relates to an implantable medical device, in particular to an implanted closed-loop deep brain stimulation system. Background technique [0002] A deep brain stimulator is an implantable medical device that is mainly used to treat movement disorders and mental disorders. Its indications include Parkinson's disease, dystonia, essential tremor, and obsessive-compulsive disorder. A deep brain stimulator generally includes a pulse generator, extension wires, and stimulating electrodes. [0003] The deep brain stimulator procedure has opened a window into the mysteries of these diseases and the brain. Through clinical records, it is found that patients with Parkinson's disease, dystonia, essential tremor and obsessive-compulsive disorder have significant differences in their corresponding stimulation targets (such as subthalamic nucleus, globus pallidus, ventral intermediate nucleus of thalamus, etc.) neuron firing characteristics. This dis...

AI Technical Summary

Problems solved by technology

However, this approach doesn't do much to improve the patient's symptoms that persist while awake

In addition, an integrated closed-loop deep brain stimulator based on sleep detection needs to integrate an additional body motion sensor to collect feedback signals, which is difficult to fully realize in the body of implantable medical devices

There is also a sleep quality assessment system that needs to use EEG signals (EEG signals do not belong to deep brain electrical signals) or an external polysomnography system to complete the judgment of sleep stages and quality, and the complexity of the system is relatively high.

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