Application of teruzhenin and its composition and pharmaceutical preparation in lipid-lowering
A technology of privetin and its composition, applied in the field of application of privetin and its composition and pharmaceutical preparations in lipid-lowering
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Embodiment 1
[0022] Example 1: The lipid-lowering effect of teruzhengside
[0023] Experimental Animals and Methods
[0024] C57BL mice, SPF grade, male, body weight (20±2) g, were randomly divided into two groups, the first group of 14 was the normal control group, given normal feed, and the remaining mice (34) were used to produce high-fat mice. The models were given high-fat feed (20% lard, 1.25% cholesterol, and 0.5% sodium cholate were added to the basic feed), and they were free to eat and drink. After 8 weeks of continuous feeding, 4 mice were sacrificed from the normal control group and the model mice respectively, and the serum and liver biochemical indicators of the two groups of mice, as well as the pathological sections of liver tissue, were compared to determine whether the model was established successfully. 30 mice successfully modeled were randomly divided into 3 groups, the model group (10 mice), the teruzhenin group (10 mice), and the positive control group (10 mice in...
Embodiment 2
[0042] Example 2: Lipid-lowering effect of combination of tergumin and lovastatin
[0043] After the animal experiment confirmed the lipid-lowering effect of privetin, the inventors continued to study whether tervetin has a synergistic lipid-lowering effect with lovastatin, a lipid-lowering drug commonly used in clinical practice. The liver is an organ for lipid synthesis. We starved the hepatocytes (LO2) for 6 hours, and then treated them with drugs for 18 hours. The lipid content in the hepatocytes was used as the drug efficacy index.
[0044] The determination method of cholesterol and triglyceride content in cells is as follows:
[0045] The content of cholesterol and triglyceride in hepatocytes was determined by the cell and tissue cholesterol and triglyceride assay kit of Beijing Pulilai Gene Technology Co., Ltd. The specific steps are as follows:
[0046] (1) Discard the supernatant, rinse twice with PBS, and digest with trypsin at 37°C for 2 minutes.
[0047] (2) A...
Embodiment 3
[0064] Embodiment 3: formulation example
[0065] Teruvirin Tablets
[0066] 10mg of privetin, 88g of starch, 3g of magnesium stearate.
[0067] Preparation process: take privetin, mix with starch and magnesium stearate evenly, make granules, dry, and compress into tablets.
[0068] Tetravirin Capsules
[0069] 10mg of privetin, 88g of starch, 3g of magnesium stearate.
[0070] Preparation process: take privetin, mix with starch and magnesium stearate evenly, make granules, dry, pack into capsules, and obtain.
[0071] Teruzhenin Injection
[0072] 47mg of privetin and 7mg of sodium chloride for injection.
[0073] Preparation process: Dissolve privetin with 1.9mL water for injection, add sodium chloride for injection to isotonicity, adjust the pH value to 7-7.1, filter, refrigerate for 24 hours, add water for injection to the specified amount, filter, Potting, sterilization, that is.
[0074] Combination Tablets of Teruzhengside and Lovastatin
[0075] 10mg of prive...
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