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Benzalkonium chloride solution and preparation method thereof

A technology of benzalkonium chloride and solution, which is applied in the field of benzalkonium chloride solution and its preparation, can solve the problems of beautifying wounds and other problems, and achieve the effects of enhanced adsorption and penetration, enhanced bactericidal effect, and good stability

Active Publication Date: 2017-02-22
广东洛斯特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent CN201310136043.8 discloses a compound disinfectant of benzalkonium chloride and sodium bicarbonate, which is formulated from benzalkonium chloride, sodium bicarbonate and water for injection, and is effective against Gram-positive bacteria, Pseudomonas aeruginosa, Both acid bacilli and bacterial spores have strong effects and will not cause strong irritation to the skin, but cannot meet the requirements of beautifying wounds

Method used

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  • Benzalkonium chloride solution and preparation method thereof
  • Benzalkonium chloride solution and preparation method thereof
  • Benzalkonium chloride solution and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032] A benzalkonium chloride solution, which comprises the following components in mass percent concentration: 0.13% benzalkonium chloride, 0.05% triclosan, 1% ethoxylated fatty acid methyl ester, 0.5% EDTA-2Na, aloe extract 5% vitamin E, 1% vitamin E, 1% sodium hyaluronate, 1.5% citric acid, and 89.82% water for injection.

[0033] Among them, C in the structure of benzalkonium chloride 12 : C 14 : C 16 =40%:30%:5%.

[0034] Its preparation method is as follows:

[0035] (1) According to the requirement of mass percentage, take each component raw material;

[0036] (2) Add the same mass of water for injection into triclosan and ethoxylated fatty acid methyl ester, heat to 60°C, stir evenly, and cool to normal temperature after fully dissolving to prepare mixed solution A;

[0037] (3) Add benzalkonium chloride, EDTA-2Na, aloe extract, vitamin E, sodium hyaluronate and citric acid to equal quality water for injection in turn, heat to 40°C, stir evenly, and cool down aft...

Embodiment 2

[0040] A benzalkonium chloride solution, which comprises the following components in mass percent concentration: 0.21% benzalkonium chloride, 0.2% triclosan, 2% ethoxylated fatty acid methyl ester, 2% EDTA-2Na, aloe extract 10% vitamin E, 5% vitamin E, 5% sodium hyaluronate, 3% malic acid, and 72.59% water for injection.

[0041] Among them, C in the structure of benzalkonium chloride 12 : C 14 : C 16 =50%:40%:10%.

[0042] Its preparation method is as follows:

[0043] (1) According to the requirement of mass percentage, take each component raw material;

[0044](2) Add the same mass of water for injection into triclosan and ethoxylated fatty acid methyl ester, heat to 80°C, stir evenly, and cool to normal temperature after fully dissolving to prepare mixed solution A;

[0045] (3) Add benzalkonium chloride, EDTA-2Na, aloe extract, vitamin E, sodium hyaluronate and malic acid to equal quality water for injection in turn, heat to 60°C, stir evenly, and cool down after ful...

Embodiment 3

[0048] A benzalkonium chloride solution, which comprises the following components in mass percent concentration: 0.17% benzalkonium chloride, 0.1% triclosan, 1.3% ethoxylated fatty acid methyl ester, 0.75% EDTA-2Na, aloe extract 8%, vitamin E 3%, sodium hyaluronate 3%, citric acid 2%, water for injection 81.68%.

[0049] Among them, C in the structure of benzalkonium chloride 12 : C 14 : C 16 =45%:35%:5%.

[0050] Its preparation method is as follows:

[0051] (1) According to the requirement of mass percentage, take each component raw material;

[0052] (2) Add the same mass of water for injection into triclosan and ethoxylated fatty acid methyl ester, heat to 70°C, stir evenly, and cool to normal temperature after fully dissolving to prepare mixed solution A;

[0053] (3) Add benzalkonium chloride, EDTA-2Na, aloe extract, vitamin E, sodium hyaluronate and citric acid to equal quality water for injection in turn, heat to 55°C, stir evenly, and cool down after fully disso...

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Abstract

The invention belongs to the field of medical sterilization and particularly relates to a benzalkonium chloride solution and a preparation method thereof. The benzalkonium chloride solution comprises, by mass, 0.13%-0.21% of benzalkonium chloride, 0.05%-0.2% of triclosan, 1%-2% of nonionic surfactant, 0.5%-2.0% of EDTA-2Na, 5%-10% of aloe extract, 1%-5% of vitamin E, 1.0%-5.0% of penetrant, 1.5%-3.0% of synergist and the balance water for injection. The benzalkonium chloride solution has the advantages of no irritation, resistance to organic matter interference, high disinfection performance and capabilities of promoting wound healing and scar fading and is applicable to cleaning and disinfection of the skin, wound mucous membranes and operative sites.

Description

technical field [0001] The invention belongs to the field of medical disinfection, and in particular relates to a benzalkonium chloride solution and a preparation method thereof. Background technique [0002] Infections such as wounds, wounds, and surgical sites can easily lead to related complications during and after surgery, and even endanger the lives of patients. Therefore, it is very important to use efficient, safe and stable medical disinfectant to clean and disinfect the patient's skin, mucous membrane and wound site before operation, and to remove bacteria and fungi on the skin surface, which is very important to reduce the rate of surgical infection. [0003] An ideal medical disinfectant should have the following characteristics: ① wide antibacterial spectrum; ② fast sterilization; ③ long-lasting bactericidal effect; ④ non-corrosive and toxic; ⑦Strong permeability; ⑧Slightly affected by organic matter, acidity and environmental factors; ⑨Does not form drug-resis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A61K9/08A61K47/18A61K47/36A61K47/12A61P31/04A61P31/10A61P29/00A61P17/02A61K31/085A61K31/14A61K31/355
CPCA61K9/08A61K31/085A61K31/14A61K31/355A61K36/886A61K36/896A61K47/12A61K47/183A61K47/36A61K2300/00
Inventor 吴琏李建德
Owner 广东洛斯特制药有限公司
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