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Composition for preventing or treating Alzheimer's disease

A technology of Alzheimer's disease and composition, applied in the field of composition, can solve problems such as heavy mental pressure and economic burden, lack of prevention or treatment of Alzheimer's disease, achieve good prevention and treatment effects, and have no toxic side effects , with a reasonable effect

Active Publication Date: 2017-02-22
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The care and treatment of patients with Alzheimer's disease has brought more and more heavy mental pressure and economic burden to families and society, and has become a serious medical and social problem facing people; however, there is currently a lack of prevention or treatment at home and abroad. Effective drug for Alzheimer's disease

Method used

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  • Composition for preventing or treating Alzheimer's disease
  • Composition for preventing or treating Alzheimer's disease
  • Composition for preventing or treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A composition for preventing or treating Alzheimer's disease, consisting of the following raw materials:

[0055]

[0056] The auxiliary material is 3 parts of starch. After adding the raw materials and auxiliary materials together, it is made into tablets, each tablet is 2g.

[0057] (1) AD transgenic nematode model experiment of embodiment 1

[0058] In the AD transgenic nematode model, the human Abeta42 peptide was expressed in the nematode body wall muscle cells and formed atheromatous protein (Abeta) deposits, and the nematodes showed muscle paralysis and progressive paralysis. The experiment found that the proportion of paralyzed nematodes cultured on medium containing different concentrations of the composition was lower than that of the nematodes cultured on solvent control medium, which showed that the rate of nematode non-paralyzed (worms not paralyzed) increased. high, such as figure 1 shown. Among them, the formula of 250ng / ml has the strongest inhibi...

Embodiment 2

[0072] A composition for preventing or treating Alzheimer's disease, consisting of the following raw materials:

[0073]

[0074] The auxiliary material is 80 parts of starch. The raw materials and auxiliary materials are added together and made into capsules, each 1g.

[0075] (1) AD transgenic nematode model experiment of embodiment two

[0076] Experiments have found that the ratio of paralysis of nematodes cultured on medium containing different concentrations of compositions is lower than that of nematodes cultured on solvent control medium, which is manifested as an increase in the non-paralyzed rate of nematodes, such as Figure 17 shown. Among them, the formula of 250ng / ml has the strongest inhibitory effect on nematode paralysis, and can significantly increase the non-paralysis rate of nematodes. When Abeta expression was induced for 80 hours, the non-paralyzed rates of nematodes cultured on 250ng / ml formula and control medium were 43% and 22%, respectively.

...

Embodiment 3

[0081] A composition for preventing or treating Alzheimer's disease, consisting of the following raw materials:

[0082]

[0083] The auxiliary materials are: 200 parts of honey, 200 parts of citric acid, and 500 L of water. The raw materials and auxiliary materials are added together to prepare an oral liquid, each 10ml.

[0084] (1) AD transgenic nematode model experiment of embodiment three

[0085] Experiments have found that the ratio of paralysis of nematodes cultured on medium containing different concentrations of compositions is lower than that of nematodes cultured on solvent control medium, which is manifested as an increase in the non-paralyzed rate of nematodes, such as Figure 20 shown. Among them, the formula of 250ng / ml has the strongest inhibitory effect on nematode paralysis, and can significantly increase the non-paralysis rate of nematodes. When Abeta expression was induced for 80 hours, the non-paralyzed rates of nematodes cultured on 250ng / ml formul...

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PUM

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Abstract

The invention discloses a composition for preventing or treating Alzheimer's disease. The composition comprises, by weight, 1-100 parts of astaxanthin, 10-100 parts of taurine, 1-50 parts of curcumin, 1-30 parts of ginkgetin, 1-50 parts of tea polyphenol, 1-50 parts of lycium barbarum polysaccharide, 1-50 parts of vitamin B12 and 1-30 parts of vitamin E. The composition can be made into tablets, capsules or oral liquid. The composition has the advantages that the formula is reasonable and ingenious, the components are interactive mutually, and accordingly, the composition can have good prevention and treatment effect on the Alzheimer's disease; the composition is safe, high in effective rate and free from any toxic and side effects.

Description

technical field [0001] The present invention relates to a composition, in particular to a composition for preventing or treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, mostly in the elderly. The main symptoms are neurofibrillary tangles (neuroFibrillarytangles, NFTs) formed by senile plaques with β-amyloid protein (Abeta) as the main component and abnormally phosphorylated tau protein in the brain of patients, as well as neuron loss. A series of advanced neurological functions such as cognition and movement of Alzheimer's disease patients will gradually become impaired, and eventually lose the ability to take care of themselves. As the global population ages, the incidence of Alzheimer's disease continues to increase around the world. In recent years, about 1.6% of people over the age of 60 in my country have been diagnosed with Alzheimer's disease, and this proportion is increasing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/82A61K9/20A61K9/48A61K9/08A61P25/28A61K31/12A61K31/122A61K31/185A61K31/352A61K31/353A61K31/355A61K31/714
CPCA61K9/0095A61K9/2059A61K9/4866A61K31/12A61K31/122A61K31/185A61K31/352A61K31/353A61K31/355A61K31/714A61K31/715A61K36/82A61K47/46A61K2300/00
Inventor 赵燕
Owner HARBIN INST OF TECH AT WEIHAI
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