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Application of traditional Chinese medicine preparation in treating and/or preventing laryngo-pharyngeal reflux

A technology for traditional Chinese medicine preparation and pharyngitis, which is applied in the field of traditional Chinese medicine, can solve the problems of poor treatment effect, long course of treatment, large dose and the like, achieves good clinical treatment effect, and the preparation process is simple, easy to operate, and simple to prepare.

Active Publication Date: 2017-02-15
北京大品种联盟科技咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, the clinical treatment of this disease is generally based on acid suppressant (proton pump inhibitor) treatment, but it often requires large doses and long courses of treatment, and the treatment effect is not good, and only for some patients with reflux pharyngitis Effective; moreover, there is no clear Chinese medicine composition for the treatment of reflux pharyngitis in domestic and foreign markets

Method used

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  • Application of traditional Chinese medicine preparation in treating and/or preventing laryngo-pharyngeal reflux
  • Application of traditional Chinese medicine preparation in treating and/or preventing laryngo-pharyngeal reflux
  • Application of traditional Chinese medicine preparation in treating and/or preventing laryngo-pharyngeal reflux

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The raw material formula of embodiment 1 Chinese medicine composition of the present invention

[0054] Composition 1: 1000g ginger pinellia, 1200g poria cocos, 900g magnolia officinalis, 600g ginger, 600g perilla leaf;

[0055] Composition 2: Pinellia 1200g, Poria cocos 1500g, Magnolia officinalis 1200g, ginger 1500g, Perilla leaf 1000g;

[0056] Composition 3: Qing Pinellia 1200g, Poria cocos 1300g, Magnolia officinalis 1000g, ginger 1000g, Perilla leaves 800g;

[0057] Composition 4: 1200g ginger pinellia, 1200g poria cocos, 900g magnolia officinalis, 600g ginger, 600g perilla leaf;

[0058] Composition 5: 1000g ginger pinellia, 1500g poria cocos, 1200g magnolia officinalis, 1500g ginger, 1000g perilla leaf;

[0059] Composition 6: Pinellia 1200g, Poria cocos 1500g, Magnolia officinalis 900g, ginger 1500g, Perilla leaves 1000g;

[0060] Composition 7: Pinellia 1000g, Poria cocos 1200g, Magnolia officinalis 1200g, ginger 600g, perilla leaves 600g;

[0061] Compos...

Embodiment 2

[0063] The preparation of embodiment 2 Chinese medicine composition extract of the present invention and the content of active substance

[0064] Take Pinellia, Poria, Magnolia officinalis, Ginger, and Su Ye from the raw material formula, add water to decoct and extract twice, add 10 times the amount of water for the first time, extract for 1.5 hours, add 8 times the amount of water for the second time, extract for 1 hour , combine the extracts, filter, and concentrate the filtrate to a clear paste with a relative density of 1.10-1.15 (50° C.), which is the extract of the traditional Chinese medicine composition of the present invention.

[0065] The compound Chinese medicine composition extract contains the following active substances: total acid (calculated as succinic acid), magnolol and honokiol, 6-gingerol (C 17 h 26 o 4 ), the results are shown in Table 1, and the determination method was in accordance with the first part of "Chinese Pharmacopoeia" (2010 edition).

...

Embodiment 3

[0068] The preparation of embodiment 3 Chinese medicine composition extract of the present invention and the content of active substance

[0069] In this experiment, supercritical CO 2 The process parameters of the extraction equipment are comprehensively studied, and various extraction conditions (extraction temperature, pressure, time, times and CO 2 flow rate) on the extraction amount and effective substance content, the impact of the number of extractions is small (extraction times 2 to 3 times, 2 times is better), extraction pressure, extraction temperature, extraction time and CO 2 The flow rate is the main influencing factor, so the influence of the four factors on the extraction effect is investigated by the orthogonal test method with the yield of total acid and extract as the index. See Table 2 for the factors and levels of investigation.

[0070] Table 2 Chinese medicine composition extraction process of the present invention investigates the factor level table ...

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Abstract

The invention provides application of a traditional Chinese medicine composition in preparing medicine for treating and / or preventing laryngo-pharyngeal reflux. The traditional Chinese medicine composition comprises, by weight, 10-12 parts of pinellia ternate preparata, 12-15 parts of poria cocos, 9-12 parts of mangnolia officinalis, 6-15 parts of ginger and 6-10 parts of perfilla leaf.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the use of a Chinese medicinal preparation of Pinellia officinalis in treating and / or preventing reflux pharyngitis. Background technique [0002] Pinellia, this product uses the dried tubers of Pinellia ternata (Thunb.) Breit., a plant of the family Araceae. It has the effects of drying dampness and resolving phlegm, lowering adverse flow and relieving vomiting, eliminating mass and resolving mass. For wet phlegm and cold phlegm, cough and dyspnea with excessive phlegm, dizziness and palpitation due to phlegm retention, wind-phlegm dizziness, syncope due to phlegm, headache, vomiting and regurgitation, fullness in the chest cavity, plume nucleus qi; external treatment of carbuncle and swollen phlegm nucleus. [0003] Wash the rhizomes of Pinellia, remove the skin and fibrous roots, and dry them in the sun to give birth to Pinellia. French Pine...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P11/04
CPCA61K36/076A61K36/535A61K36/575A61K36/8888A61K36/9068A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 杨洪军吴宏伟
Owner 北京大品种联盟科技咨询有限公司
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