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Antibacterial carboxymethyl chitosan hydrogel and preparation method thereof

A technology of carboxymethyl chitosan water and carboxymethyl chitosan, which is applied in the field of biomedical gel, can solve the problems of practical application limitation and difficulty of chitosan, and achieves simple system, high gel plasticity and rapid reaction Effect

Inactive Publication Date: 2017-02-08
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Problems solved by technology

However, because chitosan is insoluble in water, its practical application has been greatly limited.

Method used

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  • Antibacterial carboxymethyl chitosan hydrogel and preparation method thereof
  • Antibacterial carboxymethyl chitosan hydrogel and preparation method thereof
  • Antibacterial carboxymethyl chitosan hydrogel and preparation method thereof

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Embodiment 1

[0023] 5g of chitosan was added into 20% (by weight) sodium hydroxide aqueous solution and stirred for a period of time. Subsequently, 15 g of chloroacetic acid was gradually added, and the reaction was continuously stirred at 40° C. for 2 h. After the reaction, the pH of the mixture was adjusted to neutral with 10% (volume ratio) acetic acid aqueous solution, and 70% (volume ratio) methanol solution was added. It was then filtered and washed well with anhydrous methanol. Finally, the obtained product was dried in a vacuum oven at 55° C. for 8 hours to obtain carboxymethyl chitosan.

[0024] 2 g of the prepared carboxymethyl chitosan was weighed and added to 1% (volume ratio) acetic acid solution to obtain a mixed solution of carboxymethyl chitosan. Take 600 μL carboxymethyl chitosan mixed solution and mix with sodium hydroxide aqueous solution (0.1 mol / L-0.5 mol / L) to obtain new carboxymethyl chitosan mixed solution solution. Subsequently, zinc nitrate solution (0.1 mol / L-...

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Abstract

The invention discloses a preparation method of antibacterial carboxymethyl chitosan hydrogel. The preparation method of the antibacterial carboxymethyl chitosan hydrogel is characterized by comprising the following steps of (1) preparing carboxymethyl chitosan; (2) combining the carboxymethyl chitosan with transition metal ions through ion complexation reaction to prepare the antibacterial carboxymethyl chitosan hydrogel. The method has the advantages that the system is simple; the reaction is fast; the gel plasticity is high, and the like. Meanwhile, the carboxymethyl chitosan in a system and the transition metal ions have good sterilization effect, so that the goal of duplex sterilization is achieved. The antibacterial carboxymethyl chitosan hydrogel is different from conventional micromolecular antibacterial agents; the more broad-spectrum antibacterial activity is realized.

Description

technical field [0001] The invention relates to a carboxymethyl chitosan antibacterial hydrogel complexed with transition metal ions and a rapid preparation method thereof, belonging to the technical field of biomedical gels. Background technique [0002] Traditional antibacterial materials mainly obtain antibacterial properties by introducing various small molecule antibacterial agents (such as antibiotics, bactericides, etc.) into the material body or its surface. However, these small molecule antibacterial agents are usually specific and easily induce bacterial drug resistance. Therefore, it is particularly important to develop antibacterial materials with broad-spectrum activity. Antibacterial hydrogels are widely used in the field of biomedical materials because of their excellent properties. Among them, compared with hydrogels prepared by chemical crosslinking reactions, supramolecular hydrogels can be obtained from low molecular weight components through non-bonding...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08K3/28C08K3/16C08B37/08
CPCC08J3/075C08B37/003C08J2305/08C08K3/16C08K3/28C08L5/08
Inventor 褚立强王海松
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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