2-oxopropionic acid p-methoxybenzoyl hydrazone di(2,4-dichlorobenzyl) tin complex and preparation method and application thereof
A kind of technology of methoxybenzoyl hydrazone bis and methoxy benzoyl hydrazide, which is applied to 2-carbonyl propionic acid p-methoxy benzoyl hydrazone bis(2,4-dichlorobenzyl) tin complex The preparation and application fields thereof can solve the problems of undiscovered compounds and the like, and achieve the effects of simple preparation method, low cost and good anticancer activity
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Embodiment 1
[0042] Preparation of 2-carbonylpropionic acid p-methoxybenzoylhydrazone bis(2,4-dichlorobenzyl)tin complex:
[0043] Add 0.510g (1.0mmol) bis(2,4-dichlorobenzyl) tin dichloride, 0.166g (1.0mmol) p-methoxybenzohydrazide, 0.115g ( 1.05mmol) of sodium pyruvate and 15mL of solvent anhydrous methanol, react at a temperature of 50~65°C for 8 h, cool, filter, and control the solvent volatilization and crystallization at 20~35°C to obtain yellow transparent crystals, namely For 2-carbonylpropionic acid p-methoxybenzoylhydrazone bis(2,4-dichlorobenzyl)tin complexes. Yield: 72.2%. Melting point: 103~105°C (dec).
[0044] Elemental analysis (C 52 h 48 Cl 8 N 4 o 10 sn 2 ): Calculated: C 44.29, H 3.43, N 3.97; Found: C 44.33, H 3.46, N 4.00.
[0045] FT-IR (KBr, ν / cm -1 ): 3447, 3060, 2957, 2932, 2838, 1675, 1601, 1580, 1470, 1385, 1250, 1169, 1023, 841, 726, 637, 591, 535, 506, 448.
[0046] 1 H NMR (500 MHz, CDCl 3 , δ / ppm): 7.83 (d, J =9.0 Hz, 2H), 7.23 (d, J =2.0Hz, ...
Embodiment 2
[0051] Preparation of 2-carbonylpropionic acid p-methoxybenzoylhydrazone bis(2,4-dichlorobenzyl)tin complex:
[0052] Add 0.510g (1.0mmol) bis(2,4-dichlorobenzyl) tin dichloride, 0.174g (1.05mmol) p-methoxybenzohydrazide, 0.126g ( 1.15mmol) of sodium pyruvate and 35mL of solvent anhydrous methanol, react at a temperature of 50~65°C for 5 h, cool, filter, and control the solvent volatilization and crystallization at 20~35°C to obtain yellow transparent crystals, namely For 2-carbonylpropionic acid p-methoxybenzoylhydrazone bis(2,4-dichlorobenzyl)tin complexes. Yield: 75.0%. Melting point: 103~105°C (dec).
[0053] Elemental analysis (C 52 h 48 Cl 8 N 4 o 10 sn 2 ): Calculated: C 44.29, H 3.43, N 3.97; Found: C 44.33, H 3.46, N 4.00.
[0054] FT-IR (KBr, ν / cm -1 ): 3447, 3060, 2957, 2932, 2838, 1675, 1601, 1580, 1470, 1385, 1250, 1169, 1023, 841, 726, 637, 591, 535, 506, 448.
[0055] 1 H NMR (500 MHz, CDCl 3 , δ / ppm): 7.83 (d, J =9.0 Hz, 2H), 7.23 (d, J =2.0Hz,...
Embodiment 3
[0060] Preparation of 2-carbonylpropionic acid p-methoxybenzoylhydrazone bis(2,4-dichlorobenzyl)tin complex:
[0061]Add 2.550g (5.0mmol) bis(2,4-dichlorobenzyl) tin dichloride, 0.847g (5.1mmol) p-methoxybenzohydrazide, 0.605g ( 5.5mmol) of sodium pyruvate and 25mL of solvent anhydrous methanol, reacted at a temperature of 50~65°C for 20 h, cooled, filtered, and controlled solvent volatilization and crystallization at 20~35°C to obtain yellow transparent crystals, namely For 2-carbonylpropionic acid p-methoxybenzoylhydrazone bis(2,4-dichlorobenzyl)tin complexes. Yield: 74.8%. Melting point: 103~105°C (dec).
[0062] Elemental analysis (C 52 h 48 Cl 8 N 4 o 10 sn 2 ): Calculated: C 44.29, H 3.43, N 3.97; Found: C 44.33, H 3.46, N 4.00.
[0063] FT-IR (KBr, ν / cm -1 ): 3447, 3060, 2957, 2932, 2838, 1675, 1601, 1580, 1470, 1385, 1250, 1169, 1023, 841, 726, 637, 591, 535, 506, 448.
[0064] 1 H NMR (500 MHz, CDCl 3 , δ / ppm): 7.83 (d, J =9.0 Hz, 2H), 7.23 (d, J =2.0...
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