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Colon-specific bioadhesive tablet containing monosialotetrahexosyl ganglioside sodium

A technology of sodium ganglioside and bioadhesion, applied in the field of medicine, can solve the problems of high cost of drug transportation, loss of pharmacological effects, and many adverse reactions, achieve good colon-targeted drug release, increase colon local concentration, reduce The effect of the risk of degradation

Active Publication Date: 2017-02-01
赛隆药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides an improved version for delivering drugs specifically targeted towards specific areas inside body tissues such as lining up blood vessels or inflamed esophagea caused due to various medical conditions like gastritis or colic ulcers. It also includes a special type that stops unwanted substances from entering our gut without being absorbed into them.

Problems solved by technology

This patents describes how certain types of compounds called GM1 act like growth factors when applied directly onto neural tissue during surgery procedures. These substances help promote new connections between brain stem axon terminals and other parts of the body where they were previously located beforehand. However, these agents may lose activity over time due to physical conditions associated with use. Therefore there needs to provide an improved formulation containing stable components while maintaining beneficial results from administered therapy.

Method used

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  • Colon-specific bioadhesive tablet containing monosialotetrahexosyl ganglioside sodium
  • Colon-specific bioadhesive tablet containing monosialotetrahexosyl ganglioside sodium
  • Colon-specific bioadhesive tablet containing monosialotetrahexosyl ganglioside sodium

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A colon-targeted bioadhesive tablet of monosialotetrahexosylganglioside sodium, comprising a drug-loaded tablet core and a coating layer wrapping the drug-loaded tablet core, each group required for preparing 100 tablets of the bioadhesive tablet The points are weighted as follows:

[0040] Drug-loaded tablet core:

[0041] Monosialotetrahexosylganglioside Sodium 3g

[0042] Pharmaceutical carrier 15g

[0043] Coating layer:

[0044]

Embodiment 2

[0046] A colon-targeted bioadhesive tablet of monosialotetrahexosylganglioside sodium, comprising a drug-loaded tablet core and a coating layer wrapping the drug-loaded tablet core, each group required for preparing 100 tablets of the bioadhesive tablet The points are weighted as follows:

[0047] Drug-loaded tablet core:

[0048] Monosialotetrahexosylganglioside Sodium 8g

[0049] Medicinal carrier 30g

[0050] Coating layer:

[0051]

[0052] The preparation method of the bioadhesive sheet comprises the following steps:

[0053] S1. Mix monosialotetrahexosylganglioside sodium and pharmaceutical carrier evenly, add an appropriate amount of 35% ethanol solution to prepare soft material, pass through a 14 mesh sieve to granulate, and pass through a 20 mesh sieve after drying to obtain drug granules , put the drug granules in the tablet machine and press the tablet to obtain the drug-loaded tablet core;

[0054] S2. Add ethyl cellulose, zein, dibutyl phthalate, steviosid...

Embodiment 3

[0057] A colon-targeted bioadhesive tablet of monosialotetrahexosylganglioside sodium, comprising a drug-loaded tablet core and a coating layer wrapping the drug-loaded tablet core, each group required for preparing 100 tablets of the bioadhesive tablet The points are weighted as follows:

[0058] Drug-loaded tablet core:

[0059] Monosialotetrahexosylganglioside Sodium 5g

[0060]Pharmaceutical carrier 20g

[0061] Coating layer:

[0062]

[0063]

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Abstract

The invention provides a colon-specific bioadhesive tablet containing monosialotetrahexosyl ganglioside sodium. The colon-specific bioadhesive tablet comprises a tablet-loaded core and a coating wrapping the tablet-loaded core, wherein the tablet-loaded core is prepared from monosialotetrahexosyl ganglioside sodium and a pharmaceutical carrier, and the coating is mainly prepared from ethyl cellulose, zein, dibutyl phthalate, stevioside and mannitol. The colon-specific bioadhesive tablet containing monosialotetrahexosyl ganglioside sodium has the high colon-specific drug release degree; due to the fact that when the bioadhesive tablet is in the stomach and the small intestines, the release degree of the active ingredients of the drug is low, the risk that the active ingredients of the drug are degraded in the stomach is reduced, and the stability of the drug in the stomach and the small intestines is improved; when the bioadhesive tablet reaches the colon, the bioadhesive tablet starts releasing the active ingredients of the drug, and therefore the pharmaceutical effect of the bioadhesive tablet is improved.

Description

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Claims

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Application Information

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Owner 赛隆药业集团股份有限公司
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