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Application of dimethyl fumarate to preparation of medicine for preventing and treating graft versus host diseases and graft versus leukemia

A dimethyl fumarate and graft-versus-host technology, which can be used in drug combinations, pharmaceutical formulations, allergic diseases, etc., can solve problems such as lack of effective drug treatment and drug side effects

Active Publication Date: 2017-01-04
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, for the prevention and treatment of graft-versus-host disease after hematopoietic stem cell transplantation, the existing drugs have certain side effects, lack of effective drug treatment, and there is no report on the prevention and treatment of aGVHD by DMF

Method used

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  • Application of dimethyl fumarate to preparation of medicine for preventing and treating graft versus host diseases and graft versus leukemia
  • Application of dimethyl fumarate to preparation of medicine for preventing and treating graft versus host diseases and graft versus leukemia
  • Application of dimethyl fumarate to preparation of medicine for preventing and treating graft versus host diseases and graft versus leukemia

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Embodiment Construction

[0030] The present invention will be described in further detail below in conjunction with specific examples, but the present invention is not limited to the following examples. Unless otherwise specified in the present invention, the raw materials are all commercially available, and the methods are conventional methods in the art.

[0031] 1: Materials and methods

[0032] (1) Animals

[0033] 7-8 weeks old SPF grade BALB / c mice (H-2 d ), weighing 20-24g; 6-8 weeks old SPF grade C57BL / 6 mice (H-2 b ), weighing 20-24 g, purchased from Shanghai Experimental Animal Center, China. All procedures were performed in accordance with the Guidelines for the Care and Use of Animals of the Committee on Animal Care and the National Institutes of Health. All experimental mice were kept in SPF (specificpathogen-free facility) level isolation cages, the feed and litter were sterilized by 60Co irradiation, the drinking water was sterilized by high temperature and high pressure and acidifi...

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Abstract

The invention relates to a purpose of dimethyl fumarate or a dimethyl fumarate-containing medicine composition to preparation of medicine. The medicine is used for preventing and treating acute graft versus host diseases after hemopoietic stem cell transplantation. Animal experiment study discovers that the dimethyl fumarate has the obvious effect of inhibiting the acute graft versus host diseases and can be used for preparing the medicine for preventing and treating graft versus host diseases and graft versus leukemia.

Description

technical field [0001] The invention relates to the application of dimethyl fumarate in the preparation of drugs for preventing and treating graft-versus-host disease and graft-versus-leukemia. Background technique [0002] Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method for the treatment of malignant hematological diseases today, and acute graft-versus-host-disease (aGVHD) is an important complication of it, aGVHD It is the pathological damage caused by T-cell-based lymphocytes in the graft to recognize host antigens for sensitization, proliferation, and differentiation, and directly or indirectly attack host tissues and organs. At present, the classic clinical routine prevention and treatment of GVHD is cyclosporine (CSA) + short-course methotrexate (MTX). However, this type of drug targets the entire immune system, which not only leads to increased infection, but also some patients will still develop severe GVHD seriously affects the...

Claims

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Application Information

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IPC IPC(8): A61K31/225A61P37/06
CPCA61K31/225
Inventor 吴德沛马守宝韩晶晶刘海燕徐杨龚欢乐刘霜竹
Owner SUZHOU UNIV
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