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Novel application of isoliquiritigenin

A technology of isoliquiritigenin and external preparations, which is applied in the field of medicine and can solve the problems that has not yet been seen with isoliquiritigenin to treat or improve psoriasis and its related symptoms

Inactive Publication Date: 2017-01-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report on the application of isoliquiritigenin in the treatment or improvement of psoriasis and its related symptoms

Method used

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  • Novel application of isoliquiritigenin
  • Novel application of isoliquiritigenin
  • Novel application of isoliquiritigenin

Examples

Experimental program
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Embodiment Construction

[0066] The above-mentioned content of the present invention is described in further detail below by the specific implementation of the embodiment form, illustrates but does not limit the present invention.

[0067] 1 Isoliquiritigenin can effectively alleviate the disease process of animal models of psoriasis

[0068] 1.1 Isoliquiritigenin has therapeutic effect on two psoriasis animal models

[0069] 1) Establishment of animal models:

[0070] K14 / VEGF transgenic mice: K14 / VEGF transgenic mice use the promoter sequence of human keratin 14 as the control sequence to specifically express mouse VEGF-A164 protein in the mouse epidermal basal layer cells, thereby making the mouse ear Psoriasis-like lesions on the skin of the face and back. The K14 / VEGF mice used in this experiment were purchased from The Jackson Laboratory in the United States, and were raised in the animal center of the State Key Laboratory of Biotherapy, Sichuan University, in a constant temperature, constant ...

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Abstract

The invention belongs to the field of medicine and specifically relates to novel application of isoliquiritigenin, more specifically to application of isoliquiritigenin in preparation of drugs used for improving and treating psoriasis, drugs used for improving or treating parakeratosis, hyperkeratosis, acanthosis and inflammatory cell infiltration, drugs used for inhibiting the expression levels of NF-kB and p-NF-kB, and drugs used for improving or treating autoimmune diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a new application of isoliquiritigenin. Background technique [0002] Licorice, Latin name Glycyrrhiza uralensis Fisch, alias sweet grass root, red licorice, etc., is a perennial herbaceous plant of the leguminous family, widely distributed in arid and semi-arid regions of China, Russia, Egypt, Greece and other countries. Licorice root can be used as medicine and has a variety of effective chemical components. It is an ancient medicinal plant with a history of 4,000 years of application. For the analysis of licorice extract, the earliest report can be found in the paper published by Trubek M in the journal Journal of the american chemical society in 1900, in which Trubek pointed out the approximate composition of licorice extract. The main components of licorice are glycyrrhizin, glycyrrhetinic acid and liquiritin. After the study of its pharmacological effects, it was found t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K31/675A61K31/519A61K31/573A61P17/06A61P37/00A61P19/02A61P29/00A61P9/10A61P11/06A61P19/08
Inventor 杨金亮伍洋平陈向征
Owner SICHUAN UNIV
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