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Grouping method and system for prognosis of radical operation of hepatocellular carcinoma for hepatocellular carcinoma patients and kit

A technology for hepatocellular carcinoma and liver cells, applied in biochemical equipment and methods, analytical materials, biomaterial analysis, etc.

Active Publication Date: 2016-12-21
冯骥良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the relationship between the expression of cytokeratin 19 (CK19) or glypican-3 (GPC3) in hepatocellular carcinoma and postoperative tumor metastasis and recurrence has been reported, the combined detection of CK19 or GPC3 has a significant effect on hepatocellular carcinoma. Subclassification and stratification of patient outcomes have not been published

Method used

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  • Grouping method and system for prognosis of radical operation of hepatocellular carcinoma for hepatocellular carcinoma patients and kit
  • Grouping method and system for prognosis of radical operation of hepatocellular carcinoma for hepatocellular carcinoma patients and kit
  • Grouping method and system for prognosis of radical operation of hepatocellular carcinoma for hepatocellular carcinoma patients and kit

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Experimental program
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Effect test

Embodiment 1

[0083] Example 1 The grouping method of the present invention is established by identifying risk factors that predict recurrence-free survival in HCC patients

[0084] 1. Patients and Methods

[0085] Patient and Tissue Samples

[0086] A total of 346 cases of surgical resection of hepatocellular carcinoma were collected between January 2007 and November 2010 in Beijing You'an Hospital affiliated to Capital Medical University and PLA 304 Hospital. This study complied with the Declaration of Helsinki and was approved by the local ethics committee, and all subjects signed informed consent. All cases had no chemotherapy, radiotherapy or interventional therapy before operation. Other inclusion criteria for surgical resection include: (1) the primary tumor, satellite lesions, and multiple lesions can be radically resected, (2) the liver function is Child–Pugh grade A or B, (3) the remaining liver after resection Sufficient to maintain physiological functions and no surgical co...

Embodiment 2

[0118] Example 2 Prognostic grouping of patients with hepatocellular carcinoma meeting the Milan criteria based on liver biopsy before radical resection of hepatocellular carcinoma (technical scheme 1)

[0119] A total of 35 surgical resection cases of hepatocellular carcinoma patients meeting the Milan criteria were collected from a tertiary A hospital in Haidian District, Beijing. All patients had undergone liver biopsy before radical resection of hepatocellular carcinoma, and obtained from the pathology database The patient's tumor differentiation degree and the results of CK19 and GPC3 immunohistochemical staining were obtained from the medical imaging department.

[0120] The method, system and kit provided by the present invention were used to group the prognosis of hepatocellular carcinoma patients meeting the Milan criteria, and the results are shown in Table 7 below.

[0121]

[0122]

[0123]

[0124] See the specific implementation process figure 2 .

...

Embodiment 3

[0127] Example 3 Prognostic grouping of hepatocellular carcinoma patients meeting the Milan criteria based on gross specimens after surgical resection after radical resection of hepatocellular carcinoma (technical scheme 2)

[0128] A total of 47 surgical resection cases of hepatocellular carcinoma patients meeting the Milan criteria were collected from a tertiary first-class hospital in Haidian District, Beijing. The patient's tumor differentiation degree and CK19 and GPC3 immunohistochemical staining results were obtained from the database of the pathology department, and the patient's imaging information was obtained from the medical imaging department and finally determined in combination with the handwritten gross specimen examination.

[0129] The method, system and kit provided by the present invention were used to group the prognosis of hepatocellular carcinoma patients meeting the Milan criteria, and the results are shown in Table 8 below.

[0130]

[0131]

...

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Abstract

The invention provides a method for evaluating postoperative recurrence risk of hepatocellular carcinoma patients prepared to be treated by radical operation of hepatocellular carcinoma on the basis of combined detection of cytokeratin 19 (CK19) and Glypican-3 (GPC3), tumor cells differentiation status and number of tumors as the indexes. According to the method, patients can be reasonably screened before operation so as to reduce metastasis and recurrence after radical operation of tumor. In addition, metastasis and recurrence risks after radical operation of hepatocellular carcinoma patients can be evaluated according to the method so as to further guide clinicians to carry out close monitoring and early treatment for cases with high risks of metastasis and recurrence.

Description

technical field [0001] The present invention belongs to the field of precision medicine, and specifically relates to a method, system and related products for prognostic analysis of hepatocellular carcinoma patients who meet the Milan criteria who are planning or have undergone radical tumor resection, through the method, system and related products The results obtained from the implementation of the method can provide intermediate or auxiliary information for the evaluation and prediction of tumor metastasis and recurrence risk in patients with hepatocellular carcinoma after radical tumor resection. Background technique [0002] Primary liver cancer is one of the malignant tumors with the highest incidence rate in the world, and more than 1 million people are newly diagnosed with this disease every year. The incidence of liver cancer in my country has always ranked first in the world, and about 230,000 people die of liver cancer every year, accounting for 53% of the deaths ...

Claims

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Application Information

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IPC IPC(8): G01N33/577G01N33/574C12Q1/02A61K49/04A61K49/06
CPCA61K49/04A61K49/06G01N33/5091G01N33/57438G01N33/577G01N2333/4722G01N2333/4742
Inventor 冯骥良
Owner 冯骥良
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