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Antibacterial chitosan dressing containing nanogold and preparation method of dressing

A nano-gold and antibacterial shell technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of the nano-gold solution is not easy to treat and repair wounds, the antibacterial performance needs to be further improved, and the process is complicated, and achieves excellent broad-spectrum antibacterial properties. , No bacterial resistance, simple process effect

Inactive Publication Date: 2016-12-07
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The gold nanoparticles synthesized in the above report need dialysis treatment, the process is more complicated, and the process needs to be further simplified; the simple gold nanometer solution is not easy to be used in clinical wound treatment and repair, and the antibacterial performance needs to be further improved
[0006] At present, there is no public literature at home and abroad to report antibacterial chitosan dressings made of gold nanoparticles with broad-spectrum antibacterial properties and low cytotoxicity.

Method used

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  • Antibacterial chitosan dressing containing nanogold and preparation method of dressing
  • Antibacterial chitosan dressing containing nanogold and preparation method of dressing
  • Antibacterial chitosan dressing containing nanogold and preparation method of dressing

Examples

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Embodiment 1

[0053] This embodiment is used to illustrate the antibacterial chitosan dressing containing nano gold of the present invention and preparation method thereof.

[0054] (1) 50g chitosan is dissolved in the 0.90mol / L acetic acid solution of 1000mL, obtains chitosan acetic acid solution;

[0055] (2) 4,6-2 amino-2-mercaptopyrimidine / metformin containing 1.5g are mixed uniformly with the chitosan acetic acid solution that step (1) obtains as the gold nanometer particle of two-component modification, static Place defoaming, then adjust solution pH value with acetic acid to be 5, obtain nano-gold chitosan spinning solution;

[0056] (3) the nano-gold chitosan spinning solution that step (2) is obtained is extruded through spinneret, enters in the sodium hydroxide solution of 1.2mol / L and solidifies, obtains the antibacterial chitosan fiber containing nano-gold;

[0057] (4) The antibacterial chitosan fiber containing nano-gold obtained in step (3) is stretched (2 times stretching a...

Embodiment 2

[0075] This embodiment is used to illustrate the antibacterial chitosan dressing containing nano gold of the present invention and preparation method thereof.

[0076] (1) 30g chitosan is dissolved in the 0.30mol / L acetic acid solution of 1000mL, obtains chitosan acetic acid solution;

[0077] (2) 4,6-2 amino-2-mercaptopyrimidine / 1-(3-chlorophenol) biguanide containing 0.003g is obtained as the nano-gold solution and step (1) of the nano-gold particles modified by the two-component small molecule The chitosan acetic acid solution is mixed uniformly, left to defoam, and then the pH value of the solution is adjusted to 4.5 with acetic acid to obtain nano-gold chitosan spinning solution;

[0078](3) the nano-gold chitosan spinning solution that step (2) is obtained is extruded through spinneret, enters in the sodium hydroxide solution of 0.5mol / L and solidifies, obtains the antibacterial chitosan fiber containing nano-gold;

[0079] (4) The antibacterial chitosan fiber containin...

Embodiment 3

[0089] This embodiment is used to illustrate the antibacterial chitosan dressing containing nano gold of the present invention and preparation method thereof.

[0090] (1) 50g chitosan is dissolved in the 0.50mol / L acetic acid solution of 1000mL, obtains chitosan acetic acid solution;

[0091] (2) will contain 0.5g of gold-platinum two-component Au 80 Pt 20 The nano-gold solution of the nanoparticles is mixed evenly with the chitosan acetic acid solution obtained in step (1), left to defoam, and then the pH value of the solution is adjusted to 5.5 with acetic acid to obtain a nano-gold chitosan spinning solution;

[0092] (3) the nano-gold chitosan spinning solution that step (2) is obtained is extruded through spinneret, enters in the sodium hydroxide solution of 0.8mol / L and solidifies, obtains the antibacterial chitosan fiber containing nano-gold;

[0093] (4) The antibacterial chitosan fiber containing nano-gold obtained in step (3) is stretched (3 times stretching at 70...

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Abstract

The invention provides an antibacterial chitosan dressing containing nanogold. The antibacterial chitosan dressing containing the nanogold is chitosan fabric containing and / or being attached with gold nanoparticles with the antibacterial effect. The prepared antibacterial chitosan dressing containing the nanogold has excellent broad-spectrum antibacterial property and does not have bacterial resistance, the antibacterial nanogold which is small in toxicity to human cells is added into the chitosan dressing, the dressing has the broad-spectrum antibacterial property and the effect of being small in toxicity to the human cells of the nanogold and the good effects of promoting healing and stopping bleeding and the biodegradability and biocompatibility of chitosan, the dressing can be used for clinical wound treatment and treatment on various wound infections such as burns, scalds and bedsore infections, and the dressing is an extremely good medical dressing. The invention further provides a preparation method and application of the antibacterial chitosan dressing.

Description

technical field [0001] The invention relates to an antibacterial chitosan dressing, in particular to an antibacterial chitosan dressing containing nano gold, and the preparation and application of the antibacterial chitosan dressing. Background technique [0002] Chitosan is a biodegradable biocompatible material. Chitosan can provide a non-protein matrix at the wound site to promote cell proliferation and tissue growth. Chitosan has a positive charge and can combine with negatively charged red blood cells to promote red blood cell aggregation and help stop bleeding. Chitosan dressing is a kind of dressing made of biological materials with excellent performance. [0003] Simple chitosan dressings do not have ideal bactericidal and antibacterial effects. Adding antibacterial agent in chitosan dressing will improve the antibacterial property of the dressing and perfect its function. Nano-silver has strong antibacterial properties, but due to the instability of nano-silver a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/28A61L15/18
CPCA61L15/46A61L15/18A61L15/28A61L2300/102A61L2300/232A61L2300/404C08L5/08
Inventor 蒋兴宇孟宏宇张伟
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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