Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Refining method for high-purity bepotastine besilate

A technology of bepotastine bepotastine and its refining method, which is applied in the fields of chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., and can solve problems such as impurity A cannot be effectively removed, impurity cannot be effectively removed, and cannot be recycled and refined. , to achieve the effects of low production cost, cost saving and simple operation

Active Publication Date: 2016-11-16
HEFEI JIUNUO MEDICAL TECH
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for effective removal of unwanted substances from certain compounds while maintaining their desired properties or quality. It achieves this through simplified operations at lower costs compared to previous methods that were more expensive but had better results than previously possible due to its simplicity.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the quality control and manufacturing process of boplatinumabolate due to its instability against heat or moisten environment. Specifically, current processes involve complicated steps such as extraction, separation, purifying, and reformation of intermediary products before final formulation. These techniques result in increased costs associated with these operations and potential contaminants present within the desired compound substance.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Refining method for high-purity bepotastine besilate
  • Refining method for high-purity bepotastine besilate
  • Refining method for high-purity bepotastine besilate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The refining method of high-purity bepotastine bepotastine in the present embodiment comprises the following steps:

[0058] 1. Add 20 g of crude bepotastine besilate to 200 ml of acetonitrile, heat to 80°C, stir to dissolve and filter, cool the filtrate to 25-30°C, stir and crystallize for 6 hours, filter, and dry the filter cake at 60°C under reduced pressure After 4 hours, 18.3 g of the primary refined product was obtained, with a yield of 91.5% and a purity of 99.89%.

[0059] 2. Add 18g of the primary refined product to 90ml of water, heat to 30-40°C, stir to dissolve, cool to -1-5°C, stir and crystallize for 6h, filter, and dry the filter cake at 40°C for 12h under reduced pressure to obtain benzenesulfonate Bepotastine pure product 16.3g, yield 90.6%, purity 99.99%.

Embodiment 2

[0061] 1. Add 20 g of crude bepotastine besilate to 300 ml of acetonitrile, heat to 60°C, stir to dissolve and filter, cool the filtrate to 10-20°C, stir and crystallize for 8 hours, filter, and dry the filter cake at 50°C under reduced pressure After 5 hours, 18.4 g of the primary refined product was obtained, with a yield of 92% and a purity of 99.90%.

[0062] 2. Add 18g of the primary refined product to 35ml of water, heat to 70°C, stir to dissolve, cool down to -1-5°C, stir and crystallize for 4h, filter, and dry the filter cake at 50°C for 10h under reduced pressure to obtain bezulbeta The pure product of Sting is 16.4g, the yield is 91.1%, and the purity is 99.96%.

Embodiment 3

[0064] 1. Add 100g of crude bepotastine besilate to 1000ml of acetonitrile, heat to 90°C, stir to dissolve and filter, cool the filtrate to 20-30°C, stir and crystallize for 6h, filter, and dry the filter cake at 70°C under reduced pressure After 4 hours, 92.8 g of the primary refined product was obtained, with a yield of 92.8% and a purity of 99.88%.

[0065] 2. Add 92g of the primary refined product to 270ml of water, heat to 50°C, stir to dissolve, cool to -1-5°C, stir and crystallize for 5h, filter, and dry the filter cake at 55°C for 10h under reduced pressure to obtain besylate The pure product of Sting is 84.8g, the yield is 92.2%, and the purity is 99.97%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a refining method for high-purity bepotastine besilate. The refining method is a solvent crystallization method adopting a crude bepotastine besilate product as a raw material and comprises the following steps: firstly, the crude bepotastine besilate product is heated and dissolved with acetonitrile and filtered, a filtrate is cooled, stirred and crystallized, crystals are filtered and dried, and primary refined product is obtained; the primary refined product is heated, stirred, dissolved in water and filtered, a filtrate is cooled, stirred and crystallized, crystals are filtered and dried, and a pure bepotastine besilate product is obtained. The method has the advantages that the operation is simple and convenient, the yield is high, the product is pure, the cost is saved and the like, the total yield is 80% or higher, the purity of the pure bepotastine besilate product is 99.9% or higher proved by HPLC detection, the isomer impurity content is reduced to 0.1% or lower from 0.4%, and other single impurity content is reduced to 0.1% or lower from 0.2%.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Owner HEFEI JIUNUO MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products