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Novel polysaccharide cellulose medical glue with high mechanical strength and wound healing promotion and preparation method thereof

A technology of mechanical strength and wound healing, applied in the field of biomedical glue, can solve the problems of promoting wound healing and antibacterial, insufficient wound repair, no protrusion, etc., to achieve the effect of promoting wound repair, promoting wound healing, and reducing scar formation

Active Publication Date: 2020-01-07
向晨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this medical glue has no outstanding wound healing and antibacterial effects except physical adhesion, and it is still insufficient in wound repair.

Method used

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  • Novel polysaccharide cellulose medical glue with high mechanical strength and wound healing promotion and preparation method thereof
  • Novel polysaccharide cellulose medical glue with high mechanical strength and wound healing promotion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0050] In one embodiment, the polyurethane modified starch adhesive is prepared by the following method:

[0051] (1) Preparation of polyurethane biuret

[0052] Add α-cyanoacrylate and polyisocyanate biuret according to n(NCO):n(OH) =1.6:1, add them into the beaker, stir well, then add α-cyanoacrylate and polyisocyanate biuret Equal quality of water, stir evenly to obtain polyurethane biuret.

[0053] (2) Preparation of polyurethane modified starch adhesive

[0054]Add 70g of purified water and 15g of starch into a water bath heating pot equipped with a mixer and a thermometer, heat and stir for about half an hour, control the temperature at 50-65°C, add 5g of hydrogen peroxide, and oxidize for more than half an hour, then control the temperature at 80 -90°C, slowly add 5g of polyurethane biuret, control the temperature at 80-90°C for polycondensation reaction for 1-2h, and the viscosity reaches 300mPa.s.

[0055] In one embodiment, the alpha-cyanoacrylate is one of octyl-...

Embodiment 1

[0066] (1) Add α-cyanoacrylate and polyisocyanate biuret according to n(NCO):n(OH) =1.6:1, add to the beaker and stir evenly, then add α-cyanoacrylate and polyisocyanate biuret Water of urea quality, stir evenly to obtain polyurethane biuret.

[0067] (2) Add 14g of purified water and 3g of starch into a water bath heating pot equipped with a mixer and a thermometer, heat and stir for about half an hour, control the temperature at 55°C, add 1g of hydrogen peroxide, and oxidize for more than half an hour, then control the temperature at Slowly add 1g of polyurethane biuret at 80°C, and conduct polycondensation reaction at 80°C for 1-2h, until the viscosity reaches 300mPa.s to obtain the polyurethane modified starch adhesive.

[0068] (3) Mix 1.8 g of sodium carboxymethyl cellulose, 0.04 g of astragalus polysaccharide, 1.5 g of polyurethane modified starch adhesive, and 1.5 g of sodium alginate, heat up to 50°C, add 95.16 g of water for injection and stir until Melt, and wait f...

Embodiment 2

[0070] (1) Add α-cyanoacrylate and polyisocyanate biuret according to n(NCO):n(OH) =1.6:1, add to the beaker and stir evenly, then add α-cyanoacrylate and polyisocyanate biuret Water of urea quality, stir evenly to obtain polyurethane biuret.

[0071] (2) Add 13g of purified water and 3g of starch into a water bath heating pot equipped with a mixer and a thermometer, heat and stir for about half an hour, control the temperature at 65°C, add 1g of hydrogen peroxide, and oxidize for more than half an hour, then control the temperature at At 90°C, slowly add 1g of polyurethane biuret, and conduct polycondensation reaction at 90°C for 1-2h, until the viscosity reaches 300mPa.s to obtain the polyurethane modified starch adhesive.

[0072] (3) Mix 1.5g sodium carboxymethylcellulose, 0.06g astragalus polysaccharide, 0.5g polyurethane modified starch adhesive, and 0.5g sodium alginate, heat up to 50°C, add 97.44g water for injection and stir until Melt, and wait for natural cooling t...

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Abstract

The invention discloses polysaccharide cellulose medical gum with high mechanical strength and capability of promoting wound healing. The polysaccharide cellulose medical gum with high mechanical strength and capability of promoting wound healing is prepared from the following raw materials: sodium carboxymethyl cellulose, astragalus polysaccharides, polyurethane modified starch adhesive, sodium alginate, water for injection and the like. The invention further discloses a preparation method of the polysaccharide cellulose medical gum with high mechanical strength and capability of promoting wound healing. The polysaccharide cellulose medical gum with high mechanical strength and capability of promoting wound healing has good physical adhesion property, is antibacterial, has effect of promoting wound healing, and has excellent biological compatibility; and the polysaccharide cellulose medical gum with high mechanical strength and capability of promoting wound healing, which is formed by optimizing a formula, is moderate in viscosity and easy to wash, a reliable, uniform and soft protecting film can be formed on a wound surface, a wet environment of the wound surface is formed, the medical gum is used for repairing cells and can inhibit scar formation, by addition of astragalus polysaccharides with high mechanical strength and capability of promoting wound healing, cell repair can be promoted, and therefore, the polysaccharide cellulose medical gum with high mechanical strength and capability of promoting wound healing has high clinical application value.

Description

technical field [0001] The invention relates to the technical field of biomedical glue, in particular to a novel polysaccharide cellulose medical glue with high mechanical strength and promoting wound healing and a preparation method thereof. Background technique [0002] After normal skin tissue is subjected to burns, scalds or other traumas, it will not only destroy the appearance but also cause functional disturbance, which will bring huge physical pain and mental pain to the patient. In the past, dressings were mainly used to cover the wound surface, which dehydrated the wound surface and caused scabs. The scabs on the wound surface obviously hindered the epithelialization of the wound surface. Seriously affect healing, etc. [0003] Medical glue can effectively improve the above side effects. The main component of existing medical glue is α-cyanoacrylate, which can polymerize quickly on biological tissues. Under the action of anions in wound blood and interstitial flu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0015A61L24/08A61L2300/232A61L2300/404A61L2300/412C08L1/286C08L3/02C08L5/04
Inventor 向晨
Owner 向晨
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