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Application of phenylpropanoids compounds and pharmaceutically acceptable salts in preparation of drugs for treating inflammation diseases

A technology for inflammatory diseases and compounds, applied in the field of medicine, can solve problems such as complex biological effects, and achieve the effect of high purity, simple structure, and simple extraction and separation methods

Active Publication Date: 2016-11-09
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many target cells for IL-6, including macrophages, liver cells, resting T cells, activated B cells, and plasma cells; its biological effects are also very complex

Method used

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  • Application of phenylpropanoids compounds and pharmaceutically acceptable salts in preparation of drugs for treating inflammation diseases
  • Application of phenylpropanoids compounds and pharmaceutically acceptable salts in preparation of drugs for treating inflammation diseases
  • Application of phenylpropanoids compounds and pharmaceutically acceptable salts in preparation of drugs for treating inflammation diseases

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Experimental program
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Effect test

Embodiment 1

[0058] The preparation of embodiment 1 phenylpropanoid compound

[0059] This embodiment provides a preparation method of phenylpropanoid compounds shown in formula (I), comprising the following steps:

[0060] S1. Take 50 kg of big-leaved jackfruit, use the root as raw material, dry it, and cut it into small pieces. Reflux extraction with 8 times the amount of 60% ethanol for 3 times, each time for 2 hours, combine the extracts, concentrate until there is no alcohol smell, and obtain the extract for later use;

[0061] S2. Dissolve the extract concentrated in step S1 in 10L of water, and use D101 macroporous adsorption resin column to elute it. The eluent is water, and the eluent is eluted for 3 column volumes. The eluate is collected and named as MM -1, standby;

[0062] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volume ratio is 25:75, and 18 column volumes are eluted, acco...

Embodiment 2

[0065] The preparation of embodiment 2 phenylpropanoid compounds

[0066] This embodiment provides a kind of preparation method of phenylpropanoid compound shown in formula (I), comprises the steps:

[0067] S1. Take 40 kg of big-leaved jackfruit, use the root as raw material, dry it, and cut it into small pieces. Reflux extraction with 6 times the amount of 50% ethanol for 2 times, each time for 1 hour, combine the extracts, concentrate until there is no alcohol smell, and obtain the extract for later use;

[0068] S2. Dissolve the concentrated extract in step S1 in 5L of water, and use D101 macroporous adsorption resin column to elute it. The eluent is ethanol and water with a volume ratio of 15:85, and eluted for 3 column volumes , collect the eluate, name it MM-1, and set aside;

[0069] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volume ratio is 20:80, and 18 column volum...

Embodiment 3

[0072] The preparation of embodiment 3 phenylpropanoid compounds

[0073] This embodiment provides a preparation method of phenylpropanoid compounds shown in formula (I), comprising the following steps:

[0074] S1. Take 60 kg of big-leaved jackfruit, use the root as raw material, dry it, and cut it into small pieces. 7 times the amount of 70% ethanol was refluxed and extracted 4 times, each time for 3 hours, the extracts were combined, concentrated until there was no alcohol smell, and the extract was obtained for later use;

[0075] S2. Dissolve the concentrated extract in step S1 in 8L of water, and use a D101 macroporous adsorption resin column to elute it. The eluent is ethanol and water with a volume ratio of 10:90, and eluted for 3 column volumes , collect the eluate, name it MM-1, and set aside;

[0076] S3. The fraction MM-1 collected in step S2 is eluted with reversed-phase ODS column chromatography, the eluent is methanol-water system, its volume ratio is 30:70, a...

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Abstract

The invention relates to the technical field of drugs, and discloses an application of phenylpropanoids compounds and pharmaceutically acceptable salts in preparation of drugs for treating inflammation diseases. The phenylpropanoids compounds can inhibit the content of a cell inflammatory factor NO, inhibits expressive effects of cell inflammatory factors TNF-alpha, IL-1beta and IL-6, has an inhibition effect on hydroxyl radicals (-OH), has anti-inflammatory and antioxidant activities, and provides a direction for development of the drugs for treating inflammation diseases, such as cervicitis, endometritis, pelvic inflammatory disease, mastitis, pharyngolaryngitis and / or arthritis and other diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a phenylpropanoid compound and a pharmaceutically acceptable salt thereof in the preparation of medicines for treating inflammatory diseases. Background technique [0002] The components extracted and separated from natural medicines have various structures and significant activities. Separation, purification, structural modification, transformation and total synthesis of the components have always been a main idea in the development of new drugs. [0003] TNF-α: It is a cytokine that can directly kill tumor cells without obvious toxicity to normal cells. It is one of the biologically active factors with the strongest direct tumor killing effect found so far, but its toxic and side effects are also very serious. [0004] IL-1β: At local low concentrations, it can co-stimulate the activation of APC and T cells, promote the proliferation of B cells and secrete...

Claims

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Application Information

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IPC IPC(8): A61K31/704C07H15/203C07H1/08A61P29/00A61P19/02A61P15/00A61P11/04A61P39/06
CPCA61K31/704C07H1/08C07H15/203
Inventor 张鹏彭开锋林丽美伍实花夏博候佘娜阳苗
Owner ZHUZHOU QIANJIN PHARMA
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