Pancreas cancer duplex detection kit

A detection kit and technology for pancreatic cancer, applied in the field of tumor marker detection kits, can solve the problems of low detection sensitivity and specificity, difficulty in detecting early tumors, and difficulty in early screening of pancreatic cancer, and achieve rapid response. , Easy operation, high sensitivity effect

Inactive Publication Date: 2016-10-26
上海埃文生物科技有限公司
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Problems solved by technology

However, early screening of pancreatic cancer is difficult, and currently it mainly relies on serum tumor markers and imaging examinations
Since the diameter of early pancreatic tumors is ≤2cm (centimeters), the sensitivity and specificity of imaging examinations are not high, and it is difficult to detect early tumors

Method used

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Embodiment Construction

[0028] Hereinafter, the present invention will be further described with reference to the embodiments and drawings. The embodiments and drawings are only used for explanation and not for limiting the protection scope of the present invention.

[0029] Threshold determination

[0030] The overall reference value of CA19-9 in healthy people is 37u / ml, and the reference value of mesothelin is 9ng / ml; according to the above threshold, the reference value of this threshold is:

[0031] [1] Wang Luowei, Li Zhaoshen, Yu Zhiliang, Zhou Guozhong. The diagnostic value of serum CA19-9 levels for pancreatic cancer. Medical Journal of Chinese People's Liberation Army. Volume 27:4, 2002(4);

[0032] [2] Raffit Hassan, Alan T. Remaley, Maureen L. Sampson. Detection and Quantitation of Serum Mesothelin, a Tumor Marker for Patients with Mesothelioma and Ovarian Cancer. Clin Cancer Res. 2006; 12:447–53

[0033] The process of preparing the CA19-9 and mesothelin combined detection and screening test card ...

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Abstract

The invention relates to a pancreas cancer duplex detection kit. The detection kit comprises (a) a CA19-9 test strip, which comprises a CA19-9 gold pad of a mouse-anti-human CA19-9 antibody containing a color developing marker, a detection line containing a mouse-anti-human CA19-9 antibody, and a cellulose nitrate membrane containing a goat-anti-mouse IgG quality control line; (b) a mesothelin test strip, which comprises a mesothelin gold pad of a mouse-anti-human mesothelin antibody containing a color developing marker, a detection line containing a mouse-anti-human mesothelin antibody, and a cellulose nitrate membrane containing a goat-anti-mouse IgG quality control line. The provided duplex detection kit has the advantages of convenient operation, quick reaction, high sensitivity, strong specificity, suitability for onsite detection, economy, and practicality.

Description

[Technical Field] [0001] The invention relates to a detection kit for tumor markers, in particular to a dual detection kit for pancreatic cancer. [Background technique] [0002] In recent years, with the rapid development of my country's economy, the incidence of pancreatic cancer has also risen rapidly. At present, the incidence rate of men is 6 / 100,000 and the incidence of women is 4 / 100,000. The 5-year survival rate is about 5%, and even treatment with drugs to maintain life is only 5-6 months, and its mortality rate ranks fourth. Clinical studies have confirmed that the resection rate of early pancreatic cancer surgery is greater than 90%, and the 5-year survival rate has increased to 37%. However, early screening of pancreatic cancer is difficult, and currently it mainly relies on serum tumor marker examination and imaging examination. Because the diameter of early pancreatic tumors is less than 2 cm (centimeters), the sensitivity and specificity of imaging examinations ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574G01N33/558
CPCG01N33/68G01N33/558G01N33/57438
Inventor 杨万春朱永琪张笑人陈云
Owner 上海埃文生物科技有限公司
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