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Method for extracting total flavonoids from boxthorn leaves

A technology of Lycium barbarum leaves and total flavonoids, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as difficulty in realizing large-scale industrial production, affecting the activity of extracts, and short extraction time. It is easy for large-scale industrial production, improves the processing capacity and efficiency of equipment, and shortens the effect of extraction and concentration time

Inactive Publication Date: 2016-10-26
NINGXIA ACADEMY OF AGRI & FORESTRY SCI
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Problems solved by technology

The water extraction method is low in cost and safe, but the extraction efficiency is low and it contains many impurities, which brings many difficulties to the subsequent separation
The alkaline solution used in alkaline water or alkaline dilute alcohol extraction method is dilute sodium hydroxide and lime water (calcium hydroxide aqueous solution). The leaching ability of sodium hydroxide aqueous solution is high, but there are many impurities that are not conducive to purification. Calcium will combine with some flavonoids to form insoluble substances, reducing the leaching rate
The microwave method overcomes some defects in the above method, but during the extraction process, the thermal effect of microwave will lead to the degradation of some thermal substances in the extract, which seriously affects the activity of the extract, and also limits the wide application of this method
Ultrasonic extraction time is short and efficient, but it is difficult to achieve large-scale industrial production

Method used

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Embodiment 1

[0025] Lycium barbarum leaves picked in October are dried at 60°C, crushed, and the particle size is 2-4 mm. Add 70% ethanol to the extraction axe, the ratio of solid to liquid (kg:L) is 1:10, and mix; extraction temperature: 85°C, total extraction time 1.5h; according to the above method, the extraction rate of flavonoids from wolfberry leaves can reach 82.5%.

[0026] Compared with the existing extraction technology, the method for extracting flavonoids from Lycium barbarum leaves by adopting high-efficiency reflux concentration extraction-column chromatography purification technology has the following advantages and significant effects: high-efficiency reflux concentration extraction can realize extraction-concentration synchronously, The extraction time can be shortened by more than 6-8 times compared with the traditional method, and the extraction rate of the extract is increased by 5-20% compared with the conventional method, which improves the processing capacity and eff...

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Abstract

The invention discloses a method for extracting total flavonoids from boxthorn leaves, and belongs to the field of natural medicine effective component extraction. The method comprises the steps that boxthorn leaves are adopted as raw materials, and a product obtained through extraction, concentration, separation, purification and drying contains rutin, quercetin, kaempferol and isorhamnetin. The preparation has the effects of good free radical resistance, oxidation resistance, aging resistance, blood fat reduction and the like, and the preparation can be widely applied to functional foods and medicine and health products. In the preparation process, ethyl alcohol is used as an extraction solvent and an eluent, and macroporous resin is adopted as a separating material. The adopted solvent is safe, free of toxicity, low in price and capable of being recycled. The production process is safe, easy, convenient to implement, free of environment pollution, easy to control and suitable for large-scale industrial production, and meanwhile further has the advantages of being high in flavone extraction rate and purity and the like.

Description

technical field [0001] The invention relates to a method for extracting total flavonoids from wolfberry leaves, in particular to a method for separating total flavonoids from wolfberry leaves by high-efficiency reflux concentration extraction-column chromatography, and belongs to the field of effective component extraction of natural medicinal materials. Background technique [0002] Extracting chemical components from plants for medicinal purposes has a history of 5,000 years in the traditional medicine of the motherland. Traditional extraction methods can be divided into two categories according to the different energy requirements of the extraction process. One is the heating extraction method, which mainly includes different methods such as decoction extraction, reflux extraction and Soxhlet extraction; the other is the soaking extraction method, which mainly includes dipping extraction and percolation extraction. Traditional extraction methods have disadvantages such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815
CPCA61K36/815A61K2236/333A61K2236/51A61K2236/53A61K2236/55
Inventor 曹有龙刘兰英袁海静
Owner NINGXIA ACADEMY OF AGRI & FORESTRY SCI
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