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Fibroin containing antibacterial far-infrared microparticles and preparation method thereof

A micron particle and far-infrared technology, applied in the field of textile materials, can solve problems such as limitations in application fields and functional limitations of silk fibroin particles, and achieve the effects of strong plasticity, stability, and good biocompatibility

Active Publication Date: 2016-10-12
广东凯迪服饰有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from this that with the help of various chemical solvents and high-tech technologies, silk fibroin particles can already be obtained, but the functionality of the silk fibroin particles is relatively limited, the application fields are limited, and there is still a long way to go before industrialized production.

Method used

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  • Fibroin containing antibacterial far-infrared microparticles and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0026] (1) Boil silk in lye for degumming, dissolve with lithium bromide solution, dialysis and purify through dialysis bag for 3 days, then concentrate to obtain silk fibroin solution with a mass fraction of 5%, wherein the relative molecular weight of silk fibroin is 110kDa.

[0027] (2) In parts by weight, adding 5 parts of particle diameters to a solution containing 20 parts of silk fibroin is the medical stone particles of 10nm with a particle diameter of 15nm and 3 parts to adjust the pH value of the solution To 7, stir well, dry at 23°C to form a film, and form a silk fibroin-gold-medicine stone mixed film.

[0028] (3) The silk fibroin-gold-medicine stone mixed film prepared in step (2) is dissolved in hexafluoroisopropanol to form a solution A in which the total mass fraction of silk fibroin, gold and medical stone is 20%, and 25 Parts of poly-L-lactic acid are dissolved in hexafluoroisopropanol to form a solution B with a mass fraction of 25%. In parts by volume, 60 ...

Embodiment 2

[0030] (1) Boil silk in lye for degumming, dissolve it with lithium bromide solution, purify it through dialysis bag for 3 days, and concentrate to obtain a silk fibroin solution with a mass fraction of 15%, wherein the relative molecular weight of silk fibroin is 20kDa.

[0031] (2) In parts by weight, adding 15 parts of particle diameters to a solution containing 40 parts of silk fibroin is the medical stone particles of 20nm with a particle diameter of 25nm and 12 parts to adjust the pH value of the solution to 8, fully stirred, and dried at 25°C to form a silk fibroin-gold-medicine stone mixed film.

[0032] (3) The silk fibroin-gold-medicine stone mixed film prepared in step (2) is dissolved in hexafluoroisopropanol to form a solution A in which the total mass fraction of silk fibroin, gold and medical stone is 35%, and 45 Parts of poly-L-lactic acid are dissolved in hexafluoroisopropanol to form a solution B with a mass fraction of 25-35%. In parts by volume, 80 parts of...

Embodiment 3

[0034] (1) Boil silk in lye for degumming, dissolve it with lithium bromide solution, purify it through dialysis bag for 3 days, and then concentrate to obtain a silk fibroin solution with a mass fraction of 10%, wherein the relative molecular weight of silk fibroin is 50kDa.

[0035] (2) In parts by weight, adding 10 parts of particle diameters to the solution containing 30 parts of silk fibroin is the medical stone particles of 15nm and 7 parts of particle diameters to adjust the pH value of the solution to 7.5, fully stirred, and dried at 24°C to form a film, forming a silk fibroin-gold-medicine stone mixed film.

[0036] (3) The silk fibroin-gold-medicine stone mixed film prepared in step (2) is dissolved in hexafluoroisopropanol to form a solution A in which the total mass fraction of silk fibroin, gold and medical stone is 25%, and 30 Parts of poly-L-lactic acid are dissolved in hexafluoroisopropanol to form a solution B with a mass fraction of 28%. In parts by volume, 6...

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Abstract

The invention provides a preparation method of fibroin containing antibacterial far-infrared microparticles. The method comprises the following steps that nanogold particles and medical stone particles are added into a silk fibroin solution, the mixture is fully stirred, a film is formed through drying, and a fibroin-gold-medical stone mixed film is formed; then the fibroin-gold-medical stone mixed film is dissolved in hexafluoroisopropanol to form a solution A, and poly-l-lactic acid is dissolved in hexafluoroisopropanol to form a solution B; the solution A and the solution B are mixed to form a solution C, and ethylene glycol diglycidyl ether is added to serve as a cross-linking agent; heating and ultrasonic treatment are carried out, standing is carried out, and centrifugal treatment is carried out to remove precipitate; drying is carried out to obtain the fibroin containing antibacterial far-infrared microparticles. The microparticles prepared through the method are high in plasticity and stability and good in biocompatibility, and further has an antibacterial healthcare effect, a far-infrared healthcare effect and the like.

Description

technical field [0001] The invention belongs to the technical field of textile materials, and in particular relates to antibacterial far-infrared micron particles containing silk fibroin and a preparation method thereof. Background technique [0002] Silk is a precious textile raw material, which has excellent comfort and skin affinity. Silk fibroin, which is prepared from silk as a raw material, is one of the natural proteins that humans have used very early. It has the advantages of high purity and wide sources. Making silk fibroin with good performance into micro-nano particles can not only reduce the structural simulation of natural biological materials, but also improve the biocompatibility of materials. [0003] At present, there are still many researches on the preparation of silk fibroin nanoparticles. Chinese patent CN 102492300B discloses a method for preparing monodisperse silk fibroin particles and a method for preparing photonic crystals. It uses potassium phos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08L67/04C08K3/08C08K3/34A61N5/06
CPCA61N5/0625A61N2005/066C08K2201/011C08L67/04C08L89/00C08L2203/02C08K3/08C08K3/34
Inventor 王文庆
Owner 广东凯迪服饰有限公司
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