Application of dehydrocamelinarum derivatives as preparation of medicaments for the treatment of cystic hydatid disease
A technology of dehydrohaeline and cystic echinococcosis, applied in the direction of drug combination, pharmaceutical formula, anti-infective drugs, etc., can solve the problems of reducing the survival rate of Echinococcus granulosus and high toxicity
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Embodiment 1
[0064] Embodiment 1: the structural general formula of dehydrohaemaline derivative is:
[0065]
[0066] Among them, R1 is selected from hydrogen, C1-4 alkyl, substituted or unsubstituted five-membered aryl or six-membered aryl, substituted or unsubstituted containing 1 to 4 heteroatoms selected from N or O or S One of five-membered heteroaryl or six-membered heteroaryl, R9 is one selected from hydrogen, C1-6 alkyl, hydroxy-C1-6 alkyl, aryl-C1-6 alkyl.
Embodiment 2
[0067] Example 2: As an optimization of the above examples, the substituents on the substituted or unsubstituted five-membered aryl or six-membered aryl are selected from hydroxyl, amino, carboxyl, halogen, nitro, C1-6 alkyl and C1- One of 6 alkoxy groups.
Embodiment 3
[0068] Embodiment 3: As the optimization of the above-mentioned embodiment, the dehydrohaemaline derivative is 1-(4-methoxy)phenyl-9-butyl-β-carboline, and its structural formula is:
[0069]
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